ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches
The ATP-binding cassette (ABC) and solute carrier (SLC) transporters play pivotal roles in cellular transport mechanisms, influencing a wide range of physiological processes and impacting various medical conditions. Recent advancements in structural biology and computational modeling have provided s...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/17/12/1602 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850037474064072704 |
|---|---|
| author | Ahmad Elbahnsi Balint Dudas Isabelle Callebaut Alexandre Hinzpeter Maria A. Miteva |
| author_facet | Ahmad Elbahnsi Balint Dudas Isabelle Callebaut Alexandre Hinzpeter Maria A. Miteva |
| author_sort | Ahmad Elbahnsi |
| collection | DOAJ |
| description | The ATP-binding cassette (ABC) and solute carrier (SLC) transporters play pivotal roles in cellular transport mechanisms, influencing a wide range of physiological processes and impacting various medical conditions. Recent advancements in structural biology and computational modeling have provided significant insights into their function and regulation. This review provides an overview of the current knowledge of human ABC and SLC transporters, emphasizing their structural and functional relationships, transport mechanisms, and the contribution of computational approaches to their understanding. Current challenges and promising future research and methodological directions are also discussed. |
| format | Article |
| id | doaj-art-0b676e8ce2da4dcd931e76c282157c55 |
| institution | DOAJ |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-0b676e8ce2da4dcd931e76c282157c552025-08-20T02:56:51ZengMDPI AGPharmaceuticals1424-82472024-11-011712160210.3390/ph17121602ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling ApproachesAhmad Elbahnsi0Balint Dudas1Isabelle Callebaut2Alexandre Hinzpeter3Maria A. Miteva4Inserm U1268 MCTR, CiTCoM UMR 8038 CNRS, Université Paris Cité, 75006 Paris, FranceInserm U1268 MCTR, CiTCoM UMR 8038 CNRS, Université Paris Cité, 75006 Paris, FranceMuséum National d’Histoire Naturelle, UMR CNRS 7590, Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie—IMPMC, Sorbonne Université, 75005 Paris, FranceCNRS, INSERM, Institut Necker Enfants Malades—INEM, Université Paris Cité, 75015 Paris, FranceInserm U1268 MCTR, CiTCoM UMR 8038 CNRS, Université Paris Cité, 75006 Paris, FranceThe ATP-binding cassette (ABC) and solute carrier (SLC) transporters play pivotal roles in cellular transport mechanisms, influencing a wide range of physiological processes and impacting various medical conditions. Recent advancements in structural biology and computational modeling have provided significant insights into their function and regulation. This review provides an overview of the current knowledge of human ABC and SLC transporters, emphasizing their structural and functional relationships, transport mechanisms, and the contribution of computational approaches to their understanding. Current challenges and promising future research and methodological directions are also discussed.https://www.mdpi.com/1424-8247/17/12/1602SLC transportersABC transporterscryo-electron microscopyartificial intelligence modelingmolecular dockingmolecular dynamics |
| spellingShingle | Ahmad Elbahnsi Balint Dudas Isabelle Callebaut Alexandre Hinzpeter Maria A. Miteva ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches Pharmaceuticals SLC transporters ABC transporters cryo-electron microscopy artificial intelligence modeling molecular docking molecular dynamics |
| title | ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches |
| title_full | ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches |
| title_fullStr | ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches |
| title_full_unstemmed | ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches |
| title_short | ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches |
| title_sort | atp binding cassette and solute carrier transporters understanding their mechanisms and drug modulation through structural and modeling approaches |
| topic | SLC transporters ABC transporters cryo-electron microscopy artificial intelligence modeling molecular docking molecular dynamics |
| url | https://www.mdpi.com/1424-8247/17/12/1602 |
| work_keys_str_mv | AT ahmadelbahnsi atpbindingcassetteandsolutecarriertransportersunderstandingtheirmechanismsanddrugmodulationthroughstructuralandmodelingapproaches AT balintdudas atpbindingcassetteandsolutecarriertransportersunderstandingtheirmechanismsanddrugmodulationthroughstructuralandmodelingapproaches AT isabellecallebaut atpbindingcassetteandsolutecarriertransportersunderstandingtheirmechanismsanddrugmodulationthroughstructuralandmodelingapproaches AT alexandrehinzpeter atpbindingcassetteandsolutecarriertransportersunderstandingtheirmechanismsanddrugmodulationthroughstructuralandmodelingapproaches AT mariaamiteva atpbindingcassetteandsolutecarriertransportersunderstandingtheirmechanismsanddrugmodulationthroughstructuralandmodelingapproaches |