Impact of Dolutegravir-based regimens on patient satisfaction and quality of life among people living with HIV: A systematic review and meta-analysis protocol
Introduction: The use of antiretroviral therapy (ART) in HIV management has closed the gap in life expectancies between Persons Living with HIV (PLHIV) and the general populace, leading to longevity among PLHIVs. However, increased life expectancies or longevity do not translate to better treatment...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
African Field Epidemiology Network
2025-08-01
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| Series: | Journal of Interventional Epidemiology and Public Health |
| Subjects: | |
| Online Access: | https://afenet-journal.org/impact-of-dolutegravir-based-regimens-on-patient-satisfaction-and-quality-of-life-among-people-living-with-hiv-a-systematic-review-and-meta-analysis-protocol/ |
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| Summary: | Introduction: The use of antiretroviral therapy (ART) in HIV management has closed the gap in life expectancies between Persons Living with HIV (PLHIV) and the general populace, leading to longevity among PLHIVs. However, increased life expectancies or longevity do not translate to better treatment satisfaction and Quality of Life (QoL). Available literature indicates a divergence in findings with regards the effect of ART on patient satisfaction levels and QoL. With dolutegravir (DTG)-based regimens currently the mainstay of HIV management, there is the need to ascertain effects of DTG on patient satisfaction and QoL among PLHIV. Thus, the aim of this study is to review the existing literature and pool the patient satisfaction levels and QoL among PLHIV exposed to DTG.
Methods: This is a systematic review and meta-analysis. Study outcomes will be the mean values of the QoL, as well as the proportions, odds ratios and risk ratios of patient satisfaction with DTG. Searches will be conducted on PubMed and Scopus databases, with search period limited to the last 10 years. Studies that reported on the effect of DTG on our outcomes of interest will be included. For studies where the study population was exposed to other integrase strand transfer inhibitors or other ART classes, we will collect data separately for the outcomes of those exposed to DTG and those of the comparator. Also, included studies will be peer-reviewed articles that utilized standardized assessment tools to evaluate QoL among PLHIV exposed to DTG. Conversely, this review will exclude case studies, commentaries, editorials, and all forms of reviews. The study will employ the Preferred Reporting Items for Systematic Review and Meta-analysis checklist. Data extraction and screening will be conducted by 4 independent reviewers. Quality assessment will be conducted using the Newcastle Ottawa Scale. Further, narrative synthesis will be conducted as well as a random effect meta-analysis to pool estimates of patient satisfaction and QoL among PLHIV. All statistical analysis will be performed using the R Studio v 4.2.1.
Results: Findings from this study will be presented at relevant theme-specific conferences and published in a peer-reviewed journal.
Conclusion: Given the global adoption of DTG-based regimens as the mainstay of current treatment guidelines, a comprehensive systematic review focusing on the effects of DTG on patient satisfaction and QoL is required. This study will represent the first study to present the estimates of patient satisfaction levels and QoL among PLHIVs exposed to DTG. Our review will provide a background for clinical decision-making and patient-centred policies.
Protocol Registration: This systematic review and meta-analysis protocol was registered on 6 February 2025 on PROSPERO with the identification number, CRD42025643301. |
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| ISSN: | 2664-2824 |