Anticipating On‐Target and Off‐Target Effects of CRISPR/Cas9 Genome Editing Via a Feedforward Neural Network Model

Anticipating On‐Target and Off‐Target Effects of CRISPR/Cas9 Genome Editing Via a Feedforward Neural Network Model

ABSTRACT Background Clustered regularly interspaced short palindromic repeats —CRISPR‐associated protein 9 (CRISPR/Cas9) is a gene editing technology that can deliver highly precise genome editing. However, it is difficult to predict both on‐ and off‐target effects of CRISPR/Cas9, which is essential...

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Bibliographic Details
Main Authors: Pavithra Nagendran, Gowtham Murugesan, Jeyakumar Natarajan
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Medicine Advances
Subjects:
clustered regularly interspaced palindromic repeats
deep learning
Feedforward Neural Network
off‐target
on‐target
Online Access:https://doi.org/10.1002/med4.70016
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