Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

Abstract Prostate cancer (PCa) stands as a leading cause of cancer‐related mortality among men, with treatment‐induced neuroendocrine prostate cancer (NEPC) posing a challenge as an ARPI‐resistant subtype. The role of transcription factors (TFs) in PCa progression and NEPC transdifferentiation remai...

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Bibliographic Details
Main Authors: Yu Wang, Hui Xue, Xiaohui Zhu, Dong Lin, Zheng Chen, Xin Dong, Junru Chen, Mingchen Shi, Yuchao Ni, Jonathan Cao, Rebecca Wu, Connie Kang, Xinyao Pang, Francesco Crea, Yen‐Yi Lin, Colin C. Collins, Martin E. Gleave, Abhijit Parolia, Arul Chinnaiyan, Christopher J. Ong, Yuzhuo Wang
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
adenocarcinoma
De‐differentiation
dormancy
lineage plasticity
NE transdifferentiation
neuroendocrine prostate cancer
Online Access:https://doi.org/10.1002/advs.202404938
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