A False Case of Clozapine-Resistant Schizophrenia

One of the subjects that most concerns physicians is treatment-resistance. About 30%–60% of schizophrenia patients do not respond adequately to antipsychotic treatment and are known as refractory schizophrenia patients. Clozapine has been the drug of choice in such cases. However, approximately 30%...

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Main Authors: J. P. Maia-de-Oliveira, J. P. Pinto, V. Alexandre, J. P. Machado-de-Sousa, S. L. Morais, C. Chaves, A. C. Sakamoto, A. W. Zuardi, J. A. S. Crippa, J. E. Hallak
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2010/534027
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author J. P. Maia-de-Oliveira
J. P. Pinto
V. Alexandre
J. P. Machado-de-Sousa
S. L. Morais
C. Chaves
A. C. Sakamoto
A. W. Zuardi
J. A. S. Crippa
J. E. Hallak
author_facet J. P. Maia-de-Oliveira
J. P. Pinto
V. Alexandre
J. P. Machado-de-Sousa
S. L. Morais
C. Chaves
A. C. Sakamoto
A. W. Zuardi
J. A. S. Crippa
J. E. Hallak
author_sort J. P. Maia-de-Oliveira
collection DOAJ
description One of the subjects that most concerns physicians is treatment-resistance. About 30%–60% of schizophrenia patients do not respond adequately to antipsychotic treatment and are known as refractory schizophrenia patients. Clozapine has been the drug of choice in such cases. However, approximately 30% of them do not respond to clozapine either. Here, we describe a patient with an initial diagnosis of refractory schizophrenia who had a history of dramatic aggressiveness. However, in this case, “refractoriness” was a wrong diagnosis. A case of psychosis secondary to epilepsy had been treated as schizophrenia for almost 20 years. Reports like this one are important because they remind us of how a thorough investigation can lead to the correct diagnosis and improve the patient's prognosis.
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spelling doaj-art-0b5d9405b3124e58aad99dbec782d0de2025-02-03T01:02:02ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/534027534027A False Case of Clozapine-Resistant SchizophreniaJ. P. Maia-de-Oliveira0J. P. Pinto1V. Alexandre2J. P. Machado-de-Sousa3S. L. Morais4C. Chaves5A. C. Sakamoto6A. W. Zuardi7J. A. S. Crippa8J. E. Hallak9Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilDepartment of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilDepartment of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilDepartment of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilDepartment of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilDepartment of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilDepartment of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilDepartment of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilDepartment of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilDepartment of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School, University of São Paulo (USP), Hospital das Clinicas, TerceiroAndar, AvenidaBandeirantes Campus Universitario, 3900, Ribeirao Preto, SP 14049-900, BrazilOne of the subjects that most concerns physicians is treatment-resistance. About 30%–60% of schizophrenia patients do not respond adequately to antipsychotic treatment and are known as refractory schizophrenia patients. Clozapine has been the drug of choice in such cases. However, approximately 30% of them do not respond to clozapine either. Here, we describe a patient with an initial diagnosis of refractory schizophrenia who had a history of dramatic aggressiveness. However, in this case, “refractoriness” was a wrong diagnosis. A case of psychosis secondary to epilepsy had been treated as schizophrenia for almost 20 years. Reports like this one are important because they remind us of how a thorough investigation can lead to the correct diagnosis and improve the patient's prognosis.http://dx.doi.org/10.1155/2010/534027
spellingShingle J. P. Maia-de-Oliveira
J. P. Pinto
V. Alexandre
J. P. Machado-de-Sousa
S. L. Morais
C. Chaves
A. C. Sakamoto
A. W. Zuardi
J. A. S. Crippa
J. E. Hallak
A False Case of Clozapine-Resistant Schizophrenia
Case Reports in Medicine
title A False Case of Clozapine-Resistant Schizophrenia
title_full A False Case of Clozapine-Resistant Schizophrenia
title_fullStr A False Case of Clozapine-Resistant Schizophrenia
title_full_unstemmed A False Case of Clozapine-Resistant Schizophrenia
title_short A False Case of Clozapine-Resistant Schizophrenia
title_sort false case of clozapine resistant schizophrenia
url http://dx.doi.org/10.1155/2010/534027
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