SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation

SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation

Abstract Background SETD2 is the sole epigenetic factor responsible for catalyzing histone 3, lysine 36, tri-methylation (H3K36me3) in mammals. Its role in regulating cellular processes such as RNA splicing, DNA repair, and spurious transcription initiation underlies its broader tumor suppressor fun...

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Main Authors: Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Liguo Wang, Sungho Kim, Xia Zhao, Louis Y. El Khoury, Shafiq Shaikh, Jian Zhong, Jeong-Heon Lee, Jolanta Grembecka, Tomasz Cierpicki, Thai H. Ho, Keith D. Robertson
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Genome Biology
Subjects:
Clear cell renal cell carcinoma (ccRCC)
SETD2
Histone 3, lysine 36, tri-methylation (H3K36me3)
NSD1
Synthetic lethality (SL)
CRISPRi
Online Access:https://doi.org/10.1186/s13059-025-03483-z
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https://doi.org/10.1186/s13059-025-03483-z

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