Liquid biopsy in cancer: current status, challenges and future prospects
Abstract Cancer has a high mortality rate across the globe, and tissue biopsy remains the gold standard for tumor diagnosis due to its high level of laboratory standardization, good consistency of results, relatively stable samples, and high accuracy of results. However, there are still many limitat...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2024-12-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-024-02021-w |
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| author | Liwei Ma Huiling Guo Yunxiang Zhao Zhibo Liu Chenran Wang Jiahao Bu Ting Sun Jianwei Wei |
| author_facet | Liwei Ma Huiling Guo Yunxiang Zhao Zhibo Liu Chenran Wang Jiahao Bu Ting Sun Jianwei Wei |
| author_sort | Liwei Ma |
| collection | DOAJ |
| description | Abstract Cancer has a high mortality rate across the globe, and tissue biopsy remains the gold standard for tumor diagnosis due to its high level of laboratory standardization, good consistency of results, relatively stable samples, and high accuracy of results. However, there are still many limitations and drawbacks in the application of tissue biopsy in tumor. The emergence of liquid biopsy provides new ideas for early diagnosis and prognosis of tumor. Compared with tissue biopsy, liquid biopsy has many advantages in the diagnosis and treatment of various types of cancer, including non-invasive, quickly and so on. Currently, the application of liquid biopsy in tumor detection has received widely attention. It is now undergoing rapid progress, and it holds significant potential for future applications. Around now, liquid biopsies encompass several components such as circulating tumor cells, circulating tumor DNA, exosomes, microRNA, circulating RNA, tumor platelets, and tumor endothelial cells. In addition, advances in the identification of liquid biopsy indicators have significantly enhanced the possibility of utilizing liquid biopsies in clinical settings. In this review, we will discuss the application, advantages and challenges of liquid biopsy in some common tumors from the perspective of diverse systems of tumors, and look forward to its future development prospects in the field of cancer diagnosis and treatment. |
| format | Article |
| id | doaj-art-0b58f33ed5374dbebd3e5c3defe79798 |
| institution | OA Journals |
| issn | 2059-3635 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj-art-0b58f33ed5374dbebd3e5c3defe797982025-08-20T02:31:00ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352024-12-019113610.1038/s41392-024-02021-wLiquid biopsy in cancer: current status, challenges and future prospectsLiwei Ma0Huiling Guo1Yunxiang Zhao2Zhibo Liu3Chenran Wang4Jiahao Bu5Ting Sun6Jianwei Wei7Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou UniversityAbstract Cancer has a high mortality rate across the globe, and tissue biopsy remains the gold standard for tumor diagnosis due to its high level of laboratory standardization, good consistency of results, relatively stable samples, and high accuracy of results. However, there are still many limitations and drawbacks in the application of tissue biopsy in tumor. The emergence of liquid biopsy provides new ideas for early diagnosis and prognosis of tumor. Compared with tissue biopsy, liquid biopsy has many advantages in the diagnosis and treatment of various types of cancer, including non-invasive, quickly and so on. Currently, the application of liquid biopsy in tumor detection has received widely attention. It is now undergoing rapid progress, and it holds significant potential for future applications. Around now, liquid biopsies encompass several components such as circulating tumor cells, circulating tumor DNA, exosomes, microRNA, circulating RNA, tumor platelets, and tumor endothelial cells. In addition, advances in the identification of liquid biopsy indicators have significantly enhanced the possibility of utilizing liquid biopsies in clinical settings. In this review, we will discuss the application, advantages and challenges of liquid biopsy in some common tumors from the perspective of diverse systems of tumors, and look forward to its future development prospects in the field of cancer diagnosis and treatment.https://doi.org/10.1038/s41392-024-02021-w |
| spellingShingle | Liwei Ma Huiling Guo Yunxiang Zhao Zhibo Liu Chenran Wang Jiahao Bu Ting Sun Jianwei Wei Liquid biopsy in cancer: current status, challenges and future prospects Signal Transduction and Targeted Therapy |
| title | Liquid biopsy in cancer: current status, challenges and future prospects |
| title_full | Liquid biopsy in cancer: current status, challenges and future prospects |
| title_fullStr | Liquid biopsy in cancer: current status, challenges and future prospects |
| title_full_unstemmed | Liquid biopsy in cancer: current status, challenges and future prospects |
| title_short | Liquid biopsy in cancer: current status, challenges and future prospects |
| title_sort | liquid biopsy in cancer current status challenges and future prospects |
| url | https://doi.org/10.1038/s41392-024-02021-w |
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