Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain
Abstract Background Analgesic treatment is the primary method for managing acute postoperative pain. Opioid analgesics are the main class of drugs used to treat moderate to severe pain, whether it is acute or chronic. These opioids differ in various ways, including their pharmacochemical properties,...
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BMC
2025-04-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-025-03084-0 |
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| author | Mateusz Szczupak Jacek Kobak Maria Cimoszko-Zauliczna Sabina Krupa‑Nurcek Anna Ingielewicz Jolanta Wierzchowska |
| author_facet | Mateusz Szczupak Jacek Kobak Maria Cimoszko-Zauliczna Sabina Krupa‑Nurcek Anna Ingielewicz Jolanta Wierzchowska |
| author_sort | Mateusz Szczupak |
| collection | DOAJ |
| description | Abstract Background Analgesic treatment is the primary method for managing acute postoperative pain. Opioid analgesics are the main class of drugs used to treat moderate to severe pain, whether it is acute or chronic. These opioids differ in various ways, including their pharmacochemical properties, distribution and absorption rates, metabolism, and elimination pathways for the drug and its metabolites. These differences result in varying degrees of analgesic efficacy, which, in clinical practice, allows for the selection of the most effective drug that maximizes pain relief while ensuring safety. Buprenorphine is a semi-synthetic opioid with properties that are not yet fully understood. It has a wide range of applications in treating both acute and chronic pain, including non-cancer and cancer-related pain. One of the most significant clinical advantages of buprenorphine is its safety profile, which includes a ceiling effect on respiratory depression, no immunosuppressive effects, inhibition of hyperalgesia, no cumulative effects in patients with renal failure, and a low risk of constipation following its use. Aim This study aims to analyze current reports on the use of intravenous buprenorphine as a first-line opioid analgesic for postoperative pain relief. The paper discusses the pharmacochemical properties of the drug and the mechanisms behind postoperative pain. Additionally, it presents the experiences of the pain management team at Copernicus Hospital in Gdansk regarding administering intravenous buprenorphine. Material and methods The current literature on buprenorphine for treating moderate to severe acute pain has been reviewed, focusing on its effectiveness in managing postoperative pain following surgical procedures. Additionally, the experience of the Copernicus Hospital pain team with buprenorphine is summarized in a brief discussion. Conclusion After reviewing current literature and recommendations, along with the experiences of the pain management team at Copernicus Hospital in Gdańsk, it can be concluded that buprenorphine is an analgesic that demonstrates a high level of efficacy and safety. When used in combination with non-opioid analgesics, buprenorphine achieves a synergistic effect, resulting in effective pain relief. This approach facilitates early patient rehabilitation and enables a swift return to normal activities, even following extensive surgical procedures. |
| format | Article |
| id | doaj-art-0b57843d5dde4b7084192e91dc97cef3 |
| institution | OA Journals |
| issn | 1471-2253 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Anesthesiology |
| spelling | doaj-art-0b57843d5dde4b7084192e91dc97cef32025-08-20T02:28:42ZengBMCBMC Anesthesiology1471-22532025-04-0125111410.1186/s12871-025-03084-0Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative painMateusz Szczupak0Jacek Kobak1Maria Cimoszko-Zauliczna2Sabina Krupa‑Nurcek3Anna Ingielewicz4Jolanta Wierzchowska5Department of Anesthesiology and Intensive Care, Copernicus HospitalDepartment of Otolaryngology, Faculty of Medicine, Medical University of GdanskDepartment of Anesthesiology and Intensive Care, Copernicus HospitalDepartment of Surgery, Institute of Medical Sciences, Medical College of Rzeszów UniversityDepartment of Emergency Medicine, Faculty of Health Science, Medical University of GdanskDepartment of Anesthesiology and Intensive Care, Copernicus HospitalAbstract Background Analgesic treatment is the primary method for managing acute postoperative pain. Opioid analgesics are the main class of drugs used to treat moderate to severe pain, whether it is acute or chronic. These opioids differ in various ways, including their pharmacochemical properties, distribution and absorption rates, metabolism, and elimination pathways for the drug and its metabolites. These differences result in varying degrees of analgesic efficacy, which, in clinical practice, allows for the selection of the most effective drug that maximizes pain relief while ensuring safety. Buprenorphine is a semi-synthetic opioid with properties that are not yet fully understood. It has a wide range of applications in treating both acute and chronic pain, including non-cancer and cancer-related pain. One of the most significant clinical advantages of buprenorphine is its safety profile, which includes a ceiling effect on respiratory depression, no immunosuppressive effects, inhibition of hyperalgesia, no cumulative effects in patients with renal failure, and a low risk of constipation following its use. Aim This study aims to analyze current reports on the use of intravenous buprenorphine as a first-line opioid analgesic for postoperative pain relief. The paper discusses the pharmacochemical properties of the drug and the mechanisms behind postoperative pain. Additionally, it presents the experiences of the pain management team at Copernicus Hospital in Gdansk regarding administering intravenous buprenorphine. Material and methods The current literature on buprenorphine for treating moderate to severe acute pain has been reviewed, focusing on its effectiveness in managing postoperative pain following surgical procedures. Additionally, the experience of the Copernicus Hospital pain team with buprenorphine is summarized in a brief discussion. Conclusion After reviewing current literature and recommendations, along with the experiences of the pain management team at Copernicus Hospital in Gdańsk, it can be concluded that buprenorphine is an analgesic that demonstrates a high level of efficacy and safety. When used in combination with non-opioid analgesics, buprenorphine achieves a synergistic effect, resulting in effective pain relief. This approach facilitates early patient rehabilitation and enables a swift return to normal activities, even following extensive surgical procedures.https://doi.org/10.1186/s12871-025-03084-0BuprenorphineAcute postoperative painOpioid analgesiaIntravenous buprenorphinePain |
| spellingShingle | Mateusz Szczupak Jacek Kobak Maria Cimoszko-Zauliczna Sabina Krupa‑Nurcek Anna Ingielewicz Jolanta Wierzchowska Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain BMC Anesthesiology Buprenorphine Acute postoperative pain Opioid analgesia Intravenous buprenorphine Pain |
| title | Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain |
| title_full | Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain |
| title_fullStr | Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain |
| title_full_unstemmed | Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain |
| title_short | Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain |
| title_sort | strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain |
| topic | Buprenorphine Acute postoperative pain Opioid analgesia Intravenous buprenorphine Pain |
| url | https://doi.org/10.1186/s12871-025-03084-0 |
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