Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case report
Primary non-Hodgkin bone lymphoma is a rare disease, and within this category, B-cell lymphoblastic lymphoma (B-LBL) is an even rare clinical entity that has only been reported in small case series or individual case reports. B-LBL can mimic Ewing’s sarcoma both clinically and histologically, leadin...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_619_23 |
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| author | Huan Chen JiaSi Li Yong Huang |
| author_facet | Huan Chen JiaSi Li Yong Huang |
| author_sort | Huan Chen |
| collection | DOAJ |
| description | Primary non-Hodgkin bone lymphoma is a rare disease, and within this category, B-cell lymphoblastic lymphoma (B-LBL) is an even rare clinical entity that has only been reported in small case series or individual case reports. B-LBL can mimic Ewing’s sarcoma both clinically and histologically, leading to misdiagnosis. We present a case of primary B-LBL of the bone in a 7-year-old girl. The tumor cells are uniform and small with a diffuse and infiltrative growth pattern similar to EWS. Immunohistochemical results are positive for CD99, Fli-1, ERG, TDT, PAX5, and CD79α, but negative for leukocyte common antigen, CD3, CD20, and NKX2.2. No other lesions are found on positron emission tomography/computed tomography imaging. Finally, primary solitary bone B-LBL of the right tibia was diagnosed. |
| format | Article |
| id | doaj-art-0b52022a05ed4aceae565df4cfe9f8a4 |
| institution | OA Journals |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-0b52022a05ed4aceae565df4cfe9f8a42025-08-20T02:16:39ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302025-01-0168121922110.4103/ijpm.ijpm_619_23Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case reportHuan ChenJiaSi LiYong HuangPrimary non-Hodgkin bone lymphoma is a rare disease, and within this category, B-cell lymphoblastic lymphoma (B-LBL) is an even rare clinical entity that has only been reported in small case series or individual case reports. B-LBL can mimic Ewing’s sarcoma both clinically and histologically, leading to misdiagnosis. We present a case of primary B-LBL of the bone in a 7-year-old girl. The tumor cells are uniform and small with a diffuse and infiltrative growth pattern similar to EWS. Immunohistochemical results are positive for CD99, Fli-1, ERG, TDT, PAX5, and CD79α, but negative for leukocyte common antigen, CD3, CD20, and NKX2.2. No other lesions are found on positron emission tomography/computed tomography imaging. Finally, primary solitary bone B-LBL of the right tibia was diagnosed.https://journals.lww.com/10.4103/ijpm.ijpm_619_23b-cells lymphoblastic lymphomaewing’s sarcomaergfli-1primary bone lymphoma |
| spellingShingle | Huan Chen JiaSi Li Yong Huang Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case report Indian Journal of Pathology and Microbiology b-cells lymphoblastic lymphoma ewing’s sarcoma erg fli-1 primary bone lymphoma |
| title | Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case report |
| title_full | Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case report |
| title_fullStr | Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case report |
| title_full_unstemmed | Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case report |
| title_short | Primary bone solitary B-cell lymphoblastic lymphoma aberrant expression Fli-1 and ERG: A case report |
| title_sort | primary bone solitary b cell lymphoblastic lymphoma aberrant expression fli 1 and erg a case report |
| topic | b-cells lymphoblastic lymphoma ewing’s sarcoma erg fli-1 primary bone lymphoma |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_619_23 |
| work_keys_str_mv | AT huanchen primarybonesolitarybcelllymphoblasticlymphomaaberrantexpressionfli1andergacasereport AT jiasili primarybonesolitarybcelllymphoblasticlymphomaaberrantexpressionfli1andergacasereport AT yonghuang primarybonesolitarybcelllymphoblasticlymphomaaberrantexpressionfli1andergacasereport |