Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorder
Abstract Rapid eye movement (REM) sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson’s disease (PD) and a potential early marker of synucleinopathy-related neurodegeneration. While striatal dopaminergic dysfunction in PD-RBD has been extensively studied, the role of extrastri...
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Nature Portfolio
2025-08-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01116-7 |
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| author | Elina Jaakkola Jani Ijas Juho Joutsa Tero Vahlberg Elina Myller Mikael Eklund Simo Nuuttila Kirsi Murtomäki Tuomas Mertsalmi Reeta Levo Tommi Noponen Toni Ihalainen Filip Scheperjans Valtteri Kaasinen |
| author_facet | Elina Jaakkola Jani Ijas Juho Joutsa Tero Vahlberg Elina Myller Mikael Eklund Simo Nuuttila Kirsi Murtomäki Tuomas Mertsalmi Reeta Levo Tommi Noponen Toni Ihalainen Filip Scheperjans Valtteri Kaasinen |
| author_sort | Elina Jaakkola |
| collection | DOAJ |
| description | Abstract Rapid eye movement (REM) sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson’s disease (PD) and a potential early marker of synucleinopathy-related neurodegeneration. While striatal dopaminergic dysfunction in PD-RBD has been extensively studied, the role of extrastriatal monoaminergic alterations -particularly those involving serotonin - remains poorly understood. In this study, 155 PD patients underwent [123I]FP-CIT SPECT imaging to assess striatal and extrastriatal tracer binding, reflecting dopaminergic and broader monoaminergic function, respectively. Probable RBD was identified using a validated single-question screening tool with high sensitivity and specificity. Patients with probable RBD (RBD + , n = 44) were compared to those without (RBD − , n = 111) using voxel-wise and region-of-interest analyses, controlling for age, sex, disease duration, motor and non-motor symptom severity, and cognitive function. No significant differences were observed in striatal dopamine transporter binding. However, RBD+ patients showed significantly higher extrastriatal binding in the prefrontal cortex (pFWE < 0.05), suggesting a potential role for altered extrastriatal monoaminergic neurotransmission, possibly involving serotonergic pathways, in PD-RBD pathophysiology. These findings should be interpreted with caution due to the non-selective binding profile of the radiotracer. |
| format | Article |
| id | doaj-art-0b4e52c13adb4173aa6445d704dbc826 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-0b4e52c13adb4173aa6445d704dbc8262025-08-20T03:42:23ZengNature Portfolionpj Parkinson's Disease2373-80572025-08-011111710.1038/s41531-025-01116-7Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorderElina Jaakkola0Jani Ijas1Juho Joutsa2Tero Vahlberg3Elina Myller4Mikael Eklund5Simo Nuuttila6Kirsi Murtomäki7Tuomas Mertsalmi8Reeta Levo9Tommi Noponen10Toni Ihalainen11Filip Scheperjans12Valtteri Kaasinen13Clinical Neurosciences, University of TurkuClinical Neurosciences, University of TurkuClinical Neurosciences, University of TurkuDepartment of Biostatistics, University of Turku and Turku University HospitalClinical Neurosciences, University of TurkuClinical Neurosciences, University of TurkuClinical Neurosciences, University of TurkuDepartment of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of HelsinkiDepartment of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of HelsinkiDepartment of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of HelsinkiDepartment of Clinical Physiology, Nuclear Medicine, Turku PET Centre and Medical Physics, Turku University Hospital and Wellbeing services county of Southwest FinlandDepartment of Clinical Physiology and Nuclear Medicine, Helsinki University Hospital and University of HelsinkiDepartment of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of HelsinkiClinical Neurosciences, University of TurkuAbstract Rapid eye movement (REM) sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson’s disease (PD) and a potential early marker of synucleinopathy-related neurodegeneration. While striatal dopaminergic dysfunction in PD-RBD has been extensively studied, the role of extrastriatal monoaminergic alterations -particularly those involving serotonin - remains poorly understood. In this study, 155 PD patients underwent [123I]FP-CIT SPECT imaging to assess striatal and extrastriatal tracer binding, reflecting dopaminergic and broader monoaminergic function, respectively. Probable RBD was identified using a validated single-question screening tool with high sensitivity and specificity. Patients with probable RBD (RBD + , n = 44) were compared to those without (RBD − , n = 111) using voxel-wise and region-of-interest analyses, controlling for age, sex, disease duration, motor and non-motor symptom severity, and cognitive function. No significant differences were observed in striatal dopamine transporter binding. However, RBD+ patients showed significantly higher extrastriatal binding in the prefrontal cortex (pFWE < 0.05), suggesting a potential role for altered extrastriatal monoaminergic neurotransmission, possibly involving serotonergic pathways, in PD-RBD pathophysiology. These findings should be interpreted with caution due to the non-selective binding profile of the radiotracer.https://doi.org/10.1038/s41531-025-01116-7 |
| spellingShingle | Elina Jaakkola Jani Ijas Juho Joutsa Tero Vahlberg Elina Myller Mikael Eklund Simo Nuuttila Kirsi Murtomäki Tuomas Mertsalmi Reeta Levo Tommi Noponen Toni Ihalainen Filip Scheperjans Valtteri Kaasinen Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorder npj Parkinson's Disease |
| title | Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorder |
| title_full | Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorder |
| title_fullStr | Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorder |
| title_full_unstemmed | Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorder |
| title_short | Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorder |
| title_sort | increased frontal 123i fp cit binding in parkinson s disease patients with self reported rem sleep behavior disorder |
| url | https://doi.org/10.1038/s41531-025-01116-7 |
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