Common pathogenetic mechanisms of inflammatory bowel diseases and atherosclerosis: a focus on cytokines
Objective: To analyze literature data and compare the common pathways of inflammation in inflammatory bowel diseases (IBD) and atherosclerosis with focus on the effects of proinflammatory cytokines on both pathologies, as well as from the perspective of potential role of gene polymorphism of proinfl...
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| Language: | Russian |
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MONIKI
2024-12-01
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| Series: | Alʹmanah Kliničeskoj Mediciny |
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| Online Access: | https://almclinmed.ru/jour/article/viewFile/17271/1709 |
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| author | Zinaida M. Zhigula Albina A. Zhilina Natalia V. Lareva |
| author_facet | Zinaida M. Zhigula Albina A. Zhilina Natalia V. Lareva |
| author_sort | Zinaida M. Zhigula |
| collection | DOAJ |
| description | Objective: To analyze literature data and compare the common pathways of inflammation in inflammatory bowel diseases (IBD) and atherosclerosis with focus on the effects of proinflammatory cytokines on both pathologies, as well as from the perspective of potential role of gene polymorphism of proinflammatory cytokines in the pathophysiology of atherosclerosis in IBD patients.
Main provisions: In IBD, a serum cytokine profile initiates and supports the chronic inflammation. The main immunological mechanisms in both IBD and atherosclerosis are mediated by hyperproduction of proinflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukins (IL) IL-1β, IL-6, IL-8, IL-12, IL-23, IL-17, and relative insufficiency of anti-inflammatory IL-4 and IL-10, with significant increase in pro-inflammatory cytokines. An association has been established between the polymorphisms of TNF-α (rs1800629), IL-8 (rs117518778, rs8057084), IL-10 (rs3024505, rs1800896), IL-12 (rs6887695, rs10045431), IL-23 (rs11209026A) candidate genes and the development of ulcerative colitis (UC). The polymorphisms of the TNF-α (rs1800629), IL-8 (rs117518778, rs8057084), IL-1β (rs16944), IL-17A (rs2275913), IL-4 (rs2243250), IL-23 (rs6682925T/C) genes are associated with a high risk of atherosclerosis. Protein tyrosine phosphatase, receptor type, C (PTPRC) was identified as the hub crosstalk gene for the comorbidity of UC and atherosclerosis. The effects of cytokine genes polymorphisms as key targets of the pathogenetically oriented IBD therapy on the development of atherosclerosis in these patients remain a poorly investigated question.
Conclusion: IBD and atherosclerosis are mediated by the shared mechanisms of enhanced synthesis of proinflammatory cytokines, as well as polymorphisms of the candidate genes. Studies on the polymorphism of proinflammatory cytokines genes and small molecules in patients with UC, as well as the association of these polymorphisms with the development of atherosclerosis would open up new possibilities for prediction of cardiovascular diseases in these patients, development of preventive measures, and for repositioning of biological therapy for the prevention and treatment of atherosclerosis. |
| format | Article |
| id | doaj-art-0b45b04a004045aeb44188c586cd1bac |
| institution | DOAJ |
| issn | 2072-0505 2587-9294 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | MONIKI |
| record_format | Article |
| series | Alʹmanah Kliničeskoj Mediciny |
| spelling | doaj-art-0b45b04a004045aeb44188c586cd1bac2025-08-20T02:50:41ZrusMONIKIAlʹmanah Kliničeskoj Mediciny2072-05052587-92942024-12-0152840541610.18786/2072-0505-2024-52-0401016Common pathogenetic mechanisms of inflammatory bowel diseases and atherosclerosis: a focus on cytokinesZinaida M. Zhigula0https://orcid.org/0000-0002-8762-9914Albina A. Zhilina1https://orcid.org/0000-0002-4405-2975Natalia V. Lareva2https://orcid.org/0000-0001-9498-9216Chita State Medical AcademyChita State Medical AcademyChita State Medical AcademyObjective: To analyze literature data and compare the common pathways of inflammation in inflammatory bowel diseases (IBD) and atherosclerosis with focus on the effects of proinflammatory cytokines on both pathologies, as well as from the perspective of potential role of gene polymorphism of proinflammatory cytokines in the pathophysiology of atherosclerosis in IBD patients. Main provisions: In IBD, a serum cytokine profile initiates and supports the chronic inflammation. The main immunological mechanisms in both IBD and atherosclerosis are mediated by hyperproduction of proinflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukins (IL) IL-1β, IL-6, IL-8, IL-12, IL-23, IL-17, and relative insufficiency of anti-inflammatory IL-4 and IL-10, with significant increase in pro-inflammatory cytokines. An association has been established between the polymorphisms of TNF-α (rs1800629), IL-8 (rs117518778, rs8057084), IL-10 (rs3024505, rs1800896), IL-12 (rs6887695, rs10045431), IL-23 (rs11209026A) candidate genes and the development of ulcerative colitis (UC). The polymorphisms of the TNF-α (rs1800629), IL-8 (rs117518778, rs8057084), IL-1β (rs16944), IL-17A (rs2275913), IL-4 (rs2243250), IL-23 (rs6682925T/C) genes are associated with a high risk of atherosclerosis. Protein tyrosine phosphatase, receptor type, C (PTPRC) was identified as the hub crosstalk gene for the comorbidity of UC and atherosclerosis. The effects of cytokine genes polymorphisms as key targets of the pathogenetically oriented IBD therapy on the development of atherosclerosis in these patients remain a poorly investigated question. Conclusion: IBD and atherosclerosis are mediated by the shared mechanisms of enhanced synthesis of proinflammatory cytokines, as well as polymorphisms of the candidate genes. Studies on the polymorphism of proinflammatory cytokines genes and small molecules in patients with UC, as well as the association of these polymorphisms with the development of atherosclerosis would open up new possibilities for prediction of cardiovascular diseases in these patients, development of preventive measures, and for repositioning of biological therapy for the prevention and treatment of atherosclerosis.https://almclinmed.ru/jour/article/viewFile/17271/1709inflammatory bowel diseasesulcerative colitiscrohn's diseaseatherosclerosischronic inflammationpro-inflammatory cytokinesgene polymorphism |
| spellingShingle | Zinaida M. Zhigula Albina A. Zhilina Natalia V. Lareva Common pathogenetic mechanisms of inflammatory bowel diseases and atherosclerosis: a focus on cytokines Alʹmanah Kliničeskoj Mediciny inflammatory bowel diseases ulcerative colitis crohn's disease atherosclerosis chronic inflammation pro-inflammatory cytokines gene polymorphism |
| title | Common pathogenetic mechanisms of inflammatory bowel diseases and atherosclerosis: a focus on cytokines |
| title_full | Common pathogenetic mechanisms of inflammatory bowel diseases and atherosclerosis: a focus on cytokines |
| title_fullStr | Common pathogenetic mechanisms of inflammatory bowel diseases and atherosclerosis: a focus on cytokines |
| title_full_unstemmed | Common pathogenetic mechanisms of inflammatory bowel diseases and atherosclerosis: a focus on cytokines |
| title_short | Common pathogenetic mechanisms of inflammatory bowel diseases and atherosclerosis: a focus on cytokines |
| title_sort | common pathogenetic mechanisms of inflammatory bowel diseases and atherosclerosis a focus on cytokines |
| topic | inflammatory bowel diseases ulcerative colitis crohn's disease atherosclerosis chronic inflammation pro-inflammatory cytokines gene polymorphism |
| url | https://almclinmed.ru/jour/article/viewFile/17271/1709 |
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