Synthetic Phage for Tissue Regeneration
Controlling structural organization and signaling motif display is of great importance to design the functional tissue regenerating materials. Synthetic phage, genetically engineered M13 bacteriophage has been recently introduced as novel tissue regeneration materials to display a high density of ce...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/192790 |
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| _version_ | 1849308460039012352 |
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| author | So Young Yoo Anna Merzlyak Seung-Wuk Lee |
| author_facet | So Young Yoo Anna Merzlyak Seung-Wuk Lee |
| author_sort | So Young Yoo |
| collection | DOAJ |
| description | Controlling structural organization and signaling motif display is of great importance to design the functional tissue regenerating materials. Synthetic phage, genetically engineered M13 bacteriophage has been recently introduced as novel tissue regeneration materials to display a high density of cell-signaling peptides on their major coat proteins for tissue regeneration purposes. Structural advantages of their long-rod shape and monodispersity can be taken together to construct nanofibrous scaffolds which support cell proliferation and differentiation as well as direct orientation of their growth in two or three dimensions. This review demonstrated how functional synthetic phage is designed and subsequently utilized for tissue regeneration that offers potential cell therapy. |
| format | Article |
| id | doaj-art-0b3f4f042acd4b2baa950623396fed0a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0b3f4f042acd4b2baa950623396fed0a2025-08-20T03:54:28ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/192790192790Synthetic Phage for Tissue RegenerationSo Young Yoo0Anna Merzlyak1Seung-Wuk Lee2Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan 626-870, Republic of KoreaDepartment of Bioengineering, University of California, Berkeley, and Physical Bioscience Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USADepartment of Bioengineering, University of California, Berkeley, and Physical Bioscience Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USAControlling structural organization and signaling motif display is of great importance to design the functional tissue regenerating materials. Synthetic phage, genetically engineered M13 bacteriophage has been recently introduced as novel tissue regeneration materials to display a high density of cell-signaling peptides on their major coat proteins for tissue regeneration purposes. Structural advantages of their long-rod shape and monodispersity can be taken together to construct nanofibrous scaffolds which support cell proliferation and differentiation as well as direct orientation of their growth in two or three dimensions. This review demonstrated how functional synthetic phage is designed and subsequently utilized for tissue regeneration that offers potential cell therapy.http://dx.doi.org/10.1155/2014/192790 |
| spellingShingle | So Young Yoo Anna Merzlyak Seung-Wuk Lee Synthetic Phage for Tissue Regeneration Mediators of Inflammation |
| title | Synthetic Phage for Tissue Regeneration |
| title_full | Synthetic Phage for Tissue Regeneration |
| title_fullStr | Synthetic Phage for Tissue Regeneration |
| title_full_unstemmed | Synthetic Phage for Tissue Regeneration |
| title_short | Synthetic Phage for Tissue Regeneration |
| title_sort | synthetic phage for tissue regeneration |
| url | http://dx.doi.org/10.1155/2014/192790 |
| work_keys_str_mv | AT soyoungyoo syntheticphagefortissueregeneration AT annamerzlyak syntheticphagefortissueregeneration AT seungwuklee syntheticphagefortissueregeneration |