Huc-MSCs-derived exosomes alleviate non-alcoholic steatohepatitis by regulating macrophages polarization through miR-24-3p/STING axis

Huc-MSCs-derived exosomes alleviate non-alcoholic steatohepatitis by regulating macrophages polarization through miR-24-3p/STING axis

Abstract Background There’s a scarcity of drugs effective against nonalcoholic steatohepatitis (NASH). Exosomes from Human umbilical cord mesenchymal stem cells (huc-MSCs) show potential in managing glycolipid metabolism and the immune response. Therefore, further investigations are required to expl...

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Bibliographic Details
Main Authors: Wei Jiang, Qingmin Zeng, Chang-Hai Liu, Yonghong Wang, Shisheng Wang, Enqiang Chen, Ming Wang, Taoyou Zhou, Lang Bai, Dongbo Wu, Hong Tang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
Nonalcoholic steatohepatitis
Mesenchymal stem cells
Exosomes
Macrophages
STING
miR-24-3p
Online Access:https://doi.org/10.1186/s13287-025-04197-6
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