Integrated single-cell and bulk RNA sequencing analysis establishes a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in neuroblastoma

Integrated single-cell and bulk RNA sequencing analysis establishes a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in neuroblastoma

Abstract Background Cancer-associated fibroblasts (CAFs) greatly contribute to the growth, invasion, metastasis and drug resistance of neuroblastoma (NB). This study aimed to construct a CAF-related prognostic model and identify the immune status of patients with NB via single-cell RNA sequencing (s...

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Bibliographic Details
Main Authors: Zhiyao Cao, Qi Wang, Yali Han, Jianwei Lin, Qi Wu, Chencheng Xu, Jingchun Lv, Lei Zhang, Hongxiang Gao, Dapeng Jiang
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Neuroblastoma
Cancer-associated fibroblasts
Therapeutic response
Prognosis
Immune infiltration
Online Access:https://doi.org/10.1007/s12672-025-03023-y
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