Large-scale foundation models and generative AI for BigData neuroscience

Recent advances in machine learning have led to revolutionary breakthroughs in computer games, image and natural language understanding, and scientific discovery. Foundation models and large-scale language models (LLMs) have recently achieved human-like intelligence thanks to BigData. With the help...

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Main Authors: Ran Wang, Zhe Sage Chen
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Neuroscience Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S0168010224000750
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author Ran Wang
Zhe Sage Chen
author_facet Ran Wang
Zhe Sage Chen
author_sort Ran Wang
collection DOAJ
description Recent advances in machine learning have led to revolutionary breakthroughs in computer games, image and natural language understanding, and scientific discovery. Foundation models and large-scale language models (LLMs) have recently achieved human-like intelligence thanks to BigData. With the help of self-supervised learning (SSL) and transfer learning, these models may potentially reshape the landscapes of neuroscience research and make a significant impact on the future. Here we present a mini-review on recent advances in foundation models and generative AI models as well as their applications in neuroscience, including natural language and speech, semantic memory, brain-machine interfaces (BMIs), and data augmentation. We argue that this paradigm-shift framework will open new avenues for many neuroscience research directions and discuss the accompanying challenges and opportunities.
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spelling doaj-art-0b330d72358d41948004d575b89eac2f2025-08-20T01:52:42ZengElsevierNeuroscience Research0168-01022025-06-0121531410.1016/j.neures.2024.06.003Large-scale foundation models and generative AI for BigData neuroscienceRan Wang0Zhe Sage Chen1Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USADepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA; Department of Neuroscience and Physiology, Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA; Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, NY 11201, USA; Corresponding author at: Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.Recent advances in machine learning have led to revolutionary breakthroughs in computer games, image and natural language understanding, and scientific discovery. Foundation models and large-scale language models (LLMs) have recently achieved human-like intelligence thanks to BigData. With the help of self-supervised learning (SSL) and transfer learning, these models may potentially reshape the landscapes of neuroscience research and make a significant impact on the future. Here we present a mini-review on recent advances in foundation models and generative AI models as well as their applications in neuroscience, including natural language and speech, semantic memory, brain-machine interfaces (BMIs), and data augmentation. We argue that this paradigm-shift framework will open new avenues for many neuroscience research directions and discuss the accompanying challenges and opportunities.http://www.sciencedirect.com/science/article/pii/S0168010224000750Foundation modelGenerative AIBigDataTransformerSelf-supervised learningTransfer learning
spellingShingle Ran Wang
Zhe Sage Chen
Large-scale foundation models and generative AI for BigData neuroscience
Neuroscience Research
Foundation model
Generative AI
BigData
Transformer
Self-supervised learning
Transfer learning
title Large-scale foundation models and generative AI for BigData neuroscience
title_full Large-scale foundation models and generative AI for BigData neuroscience
title_fullStr Large-scale foundation models and generative AI for BigData neuroscience
title_full_unstemmed Large-scale foundation models and generative AI for BigData neuroscience
title_short Large-scale foundation models and generative AI for BigData neuroscience
title_sort large scale foundation models and generative ai for bigdata neuroscience
topic Foundation model
Generative AI
BigData
Transformer
Self-supervised learning
Transfer learning
url http://www.sciencedirect.com/science/article/pii/S0168010224000750
work_keys_str_mv AT ranwang largescalefoundationmodelsandgenerativeaiforbigdataneuroscience
AT zhesagechen largescalefoundationmodelsandgenerativeaiforbigdataneuroscience