Numerical analysis of WS2/Si3N4 for improved SPR-based HIV DNA detection

Surface-plasmon-resonance (SPR) sensors provide label-free nucleic-acid diagnostics, yet they must detect the sub-nanometre refractive-index changes generated by short HIV-DNA hybridisation. Using a transfer-matrix framework, we design a multilayer architecture that couples a 50 nm silver mirror to...

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Bibliographic Details
Main Authors:	Talia Tene, Yesenia Cevallos, Jessica Alexandra Marcatoma Tixi, Natalia Alexandra Pérez Londo, Lala Gahramanli, Cristian Vacacela Gomez
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Bioengineering and Biotechnology
Subjects:	surface plasmon resonance HIV DNA hybridization kretschmann configuration transfer matrix method silicon nitride tungsten disulfide
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1577925/full
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Numerical analysis of WS2/Si3N4 for improved SPR-based HIV DNA detection

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