A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Abstract Diabetic cardiomyopathy (DbCM) is increasingly prevalent, but intervention targets remain unclear due to the lack of appropriate models and the complexity of risk factors. Here, this work establishes an in vitro assessment system for DbCM function using cardiomyocytes derived from human plu...

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Bibliographic Details
Main Authors: Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
diabetic cardiomyopathy
diastolic dysfunction
empagliflozin
hEHT
in vitro model
Online Access:https://doi.org/10.1002/advs.202503173
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