Granuloma Annulare in the Setting of Secukinumab

Granuloma annulare (GA) is a common benign inflammatory skin condition classically presenting as skin-colored to erythematous dermal papules and annular plaques. Histologically, GA displays a dermal granulomatous infiltrate with palisaded histiocytes surrounding focally altered collagen. The exactly...

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Main Authors: Matthew L. Clark, Courtney A. Tobin, Angela Sutton, Tricia Ann Missall
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Case Reports in Dermatological Medicine
Online Access:http://dx.doi.org/10.1155/2018/5175319
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author Matthew L. Clark
Courtney A. Tobin
Angela Sutton
Tricia Ann Missall
author_facet Matthew L. Clark
Courtney A. Tobin
Angela Sutton
Tricia Ann Missall
author_sort Matthew L. Clark
collection DOAJ
description Granuloma annulare (GA) is a common benign inflammatory skin condition classically presenting as skin-colored to erythematous dermal papules and annular plaques. Histologically, GA displays a dermal granulomatous infiltrate with palisaded histiocytes surrounding focally altered collagen. The exactly etiology of GA remains unknown, but it has been associated with trauma, various infections, diabetes mellitus, malignancy, thyroid disease, dyslipidemia, and several medications. In 2017, a case of GA developing in a patient treated with the interleukin 17A antagonist secukinumab was reported. Here we report a second case of GA in association with secukinumab use.
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series Case Reports in Dermatological Medicine
spelling doaj-art-0b1fb960ce3540f59130784eeea372f52025-08-20T03:54:28ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712018-01-01201810.1155/2018/51753195175319Granuloma Annulare in the Setting of SecukinumabMatthew L. Clark0Courtney A. Tobin1Angela Sutton2Tricia Ann Missall3Department of Dermatology, Saint Louis University, 1755 S. Grand Blvd., Saint Louis, MO 63104, USADistinctive Dermatology, 510 Fullerton Rd., Swansea, IL 62226, USADepartment of Dermatology, Saint Louis University, 1755 S. Grand Blvd., Saint Louis, MO 63104, USADepartment of Dermatology, Saint Louis University, 1755 S. Grand Blvd., Saint Louis, MO 63104, USAGranuloma annulare (GA) is a common benign inflammatory skin condition classically presenting as skin-colored to erythematous dermal papules and annular plaques. Histologically, GA displays a dermal granulomatous infiltrate with palisaded histiocytes surrounding focally altered collagen. The exactly etiology of GA remains unknown, but it has been associated with trauma, various infections, diabetes mellitus, malignancy, thyroid disease, dyslipidemia, and several medications. In 2017, a case of GA developing in a patient treated with the interleukin 17A antagonist secukinumab was reported. Here we report a second case of GA in association with secukinumab use.http://dx.doi.org/10.1155/2018/5175319
spellingShingle Matthew L. Clark
Courtney A. Tobin
Angela Sutton
Tricia Ann Missall
Granuloma Annulare in the Setting of Secukinumab
Case Reports in Dermatological Medicine
title Granuloma Annulare in the Setting of Secukinumab
title_full Granuloma Annulare in the Setting of Secukinumab
title_fullStr Granuloma Annulare in the Setting of Secukinumab
title_full_unstemmed Granuloma Annulare in the Setting of Secukinumab
title_short Granuloma Annulare in the Setting of Secukinumab
title_sort granuloma annulare in the setting of secukinumab
url http://dx.doi.org/10.1155/2018/5175319
work_keys_str_mv AT matthewlclark granulomaannulareinthesettingofsecukinumab
AT courtneyatobin granulomaannulareinthesettingofsecukinumab
AT angelasutton granulomaannulareinthesettingofsecukinumab
AT triciaannmissall granulomaannulareinthesettingofsecukinumab