From research to reality: A review of three clinical problems in the last days of life
All of us will one day die. For most of us, death will be anticipated, usually following a period of ill health. The opportunity to anticipate and manage clinical conditions associated with the agonal process is an essential part of advance care planning.Guidelines exist for the palliation of most s...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Clinical Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1470211825002040 |
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| author | Tasneem Wadee Simon Noble |
| author_facet | Tasneem Wadee Simon Noble |
| author_sort | Tasneem Wadee |
| collection | DOAJ |
| description | All of us will one day die. For most of us, death will be anticipated, usually following a period of ill health. The opportunity to anticipate and manage clinical conditions associated with the agonal process is an essential part of advance care planning.Guidelines exist for the palliation of most symptomatic events at the end of life, although many recommendations are based on low-quality evidence or consensus. Furthermore, when potentially practice-changing data emerge, there is an inevitable lag time before clinical practice changes.In this paper, we shall discuss the management of three challenging scenarios faced by teams looking after patients at the end of life: delirium, terminal haemorrhage and noisy upper airway secretions. We aim to critically evaluate the utility of current evidence, pharmacological and non-pharmacological, and how it translates into clinical practice. |
| format | Article |
| id | doaj-art-0b1c2fa64bea4b8bb0dbafcc69caf04b |
| institution | Kabale University |
| issn | 1470-2118 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Medicine |
| spelling | doaj-art-0b1c2fa64bea4b8bb0dbafcc69caf04b2025-08-20T03:59:37ZengElsevierClinical Medicine1470-21182025-07-0125410048610.1016/j.clinme.2025.100486From research to reality: A review of three clinical problems in the last days of lifeTasneem Wadee0Simon Noble1Internal Medicine Trainee, Aneurin Bevan University Health Board, Gwent, Wales, UKSupportive and Palliative Medicine, Cardiff University, Cardiff, Wales, UK; Corresponding author.All of us will one day die. For most of us, death will be anticipated, usually following a period of ill health. The opportunity to anticipate and manage clinical conditions associated with the agonal process is an essential part of advance care planning.Guidelines exist for the palliation of most symptomatic events at the end of life, although many recommendations are based on low-quality evidence or consensus. Furthermore, when potentially practice-changing data emerge, there is an inevitable lag time before clinical practice changes.In this paper, we shall discuss the management of three challenging scenarios faced by teams looking after patients at the end of life: delirium, terminal haemorrhage and noisy upper airway secretions. We aim to critically evaluate the utility of current evidence, pharmacological and non-pharmacological, and how it translates into clinical practice.http://www.sciencedirect.com/science/article/pii/S1470211825002040Terminal deliriumDeliriumTerminal haemorrhageSecretionsTerminal secretionsEnd of life care |
| spellingShingle | Tasneem Wadee Simon Noble From research to reality: A review of three clinical problems in the last days of life Clinical Medicine Terminal delirium Delirium Terminal haemorrhage Secretions Terminal secretions End of life care |
| title | From research to reality: A review of three clinical problems in the last days of life |
| title_full | From research to reality: A review of three clinical problems in the last days of life |
| title_fullStr | From research to reality: A review of three clinical problems in the last days of life |
| title_full_unstemmed | From research to reality: A review of three clinical problems in the last days of life |
| title_short | From research to reality: A review of three clinical problems in the last days of life |
| title_sort | from research to reality a review of three clinical problems in the last days of life |
| topic | Terminal delirium Delirium Terminal haemorrhage Secretions Terminal secretions End of life care |
| url | http://www.sciencedirect.com/science/article/pii/S1470211825002040 |
| work_keys_str_mv | AT tasneemwadee fromresearchtorealityareviewofthreeclinicalproblemsinthelastdaysoflife AT simonnoble fromresearchtorealityareviewofthreeclinicalproblemsinthelastdaysoflife |