Overeating Behavior and Striatal Dopamine with 6-[18F]-Fluoro-L-𝑚-Tyrosine PET
Eating behavior may be affected by dopamine synthesis capacity. In this study, 6-[18F]-fluoro-L-𝑚-tyrosine (FMT) positron emission tomography (PET) uptake in striatal subregions was correlated with BMI (kg/m2) and an estimate of the frequency of prior weight loss attempts in 15 healthy subjects. B...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2010/909348 |
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| author | Claire E. Wilcox Meredith N. Braskie Jennifer T. Kluth William J. Jagust |
| author_facet | Claire E. Wilcox Meredith N. Braskie Jennifer T. Kluth William J. Jagust |
| author_sort | Claire E. Wilcox |
| collection | DOAJ |
| description | Eating behavior may be affected by dopamine synthesis capacity. In this study, 6-[18F]-fluoro-L-𝑚-tyrosine (FMT) positron emission tomography (PET) uptake in striatal subregions was correlated with BMI (kg/m2) and an estimate of the frequency of prior weight loss attempts in 15 healthy subjects. BMI was negatively correlated with FMT uptake in the dorsal caudate. Although the association between BMI and FMT uptake in the dorsal caudate was not significant upon correction for age and sex, the association fell within the range of a statistical trend. Weight loss attempts divided by years trying was also negatively correlated with FMT uptake in the dorsal putamen (𝑃=.05). These results suggest an association between low dorsal striatal presynaptic dopamine synthesis capacity and overeating behavior. |
| format | Article |
| id | doaj-art-0b1c284ad8f2484fbbba2dba94be03ed |
| institution | OA Journals |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-0b1c284ad8f2484fbbba2dba94be03ed2025-08-20T02:03:08ZengWileyJournal of Obesity2090-07082090-07162010-01-01201010.1155/2010/909348909348Overeating Behavior and Striatal Dopamine with 6-[18F]-Fluoro-L-𝑚-Tyrosine PETClaire E. Wilcox0Meredith N. Braskie1Jennifer T. Kluth2William J. Jagust3Department of Psychiatry, University of California at San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, USAHelen Wills Neuroscience Institute, MC #3190, University of California at Berkeley, 132 Barker Hall, Berkeley, CA 94720-3192, USAHelen Wills Neuroscience Institute, MC #3190, University of California at Berkeley, 132 Barker Hall, Berkeley, CA 94720-3192, USAHelen Wills Neuroscience Institute, MC #3190, University of California at Berkeley, 132 Barker Hall, Berkeley, CA 94720-3192, USAEating behavior may be affected by dopamine synthesis capacity. In this study, 6-[18F]-fluoro-L-𝑚-tyrosine (FMT) positron emission tomography (PET) uptake in striatal subregions was correlated with BMI (kg/m2) and an estimate of the frequency of prior weight loss attempts in 15 healthy subjects. BMI was negatively correlated with FMT uptake in the dorsal caudate. Although the association between BMI and FMT uptake in the dorsal caudate was not significant upon correction for age and sex, the association fell within the range of a statistical trend. Weight loss attempts divided by years trying was also negatively correlated with FMT uptake in the dorsal putamen (𝑃=.05). These results suggest an association between low dorsal striatal presynaptic dopamine synthesis capacity and overeating behavior.http://dx.doi.org/10.1155/2010/909348 |
| spellingShingle | Claire E. Wilcox Meredith N. Braskie Jennifer T. Kluth William J. Jagust Overeating Behavior and Striatal Dopamine with 6-[18F]-Fluoro-L-𝑚-Tyrosine PET Journal of Obesity |
| title | Overeating Behavior and Striatal Dopamine with 6-[18F]-Fluoro-L-𝑚-Tyrosine PET |
| title_full | Overeating Behavior and Striatal Dopamine with 6-[18F]-Fluoro-L-𝑚-Tyrosine PET |
| title_fullStr | Overeating Behavior and Striatal Dopamine with 6-[18F]-Fluoro-L-𝑚-Tyrosine PET |
| title_full_unstemmed | Overeating Behavior and Striatal Dopamine with 6-[18F]-Fluoro-L-𝑚-Tyrosine PET |
| title_short | Overeating Behavior and Striatal Dopamine with 6-[18F]-Fluoro-L-𝑚-Tyrosine PET |
| title_sort | overeating behavior and striatal dopamine with 6 18f fluoro l 𝑚 tyrosine pet |
| url | http://dx.doi.org/10.1155/2010/909348 |
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