A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer

A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer

Abstract Salivary gland cancers are rare, diverse malignancies characterized by poor response to immunotherapy. The tumor immune environment in these cancers remains poorly understood. To address this, we perform an integrative analysis of the tumor immune microenvironment in a large cohort of advan...

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Main Authors: Erika Zuljan, Benjamin von der Emde, Iris Piwonski, Ana Pestana, Konrad Klinghammer, Andreas Mock, Peter Horak, Christoph Heining, Frederick Klauschen, Ina Pretzell, Melanie Boerries, Christian H. Brandts, Simon Kreutzfeldt, Maria-Veronica Teleanu, Daniel Hübschmann, Luc G. T. Morris, Max Heiland, Ulrich Keller, Thomas Conrad, Hanno Glimm, Stefan Fröhling, Sebastian Ochsenreither, Ulrich Keilholz, Eric Blanc, Dieter Beule, Damian T. Rieke
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60421-0
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