The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances
Cardiovascular diseases are a major global health concern, leading to high morbidity, mortality, and disability rates. Scaffold proteins, particularly A-kinase anchoring proteins (AKAPs), play a crucial role in signal transduction within the cardiovascular system. This review provides a comprehensiv...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1611583/full |
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| author | Xu Zhang Xu Zhang Feng Zhu Zhaoqiang Xiao Hegui Wang |
| author_facet | Xu Zhang Xu Zhang Feng Zhu Zhaoqiang Xiao Hegui Wang |
| author_sort | Xu Zhang |
| collection | DOAJ |
| description | Cardiovascular diseases are a major global health concern, leading to high morbidity, mortality, and disability rates. Scaffold proteins, particularly A-kinase anchoring proteins (AKAPs), play a crucial role in signal transduction within the cardiovascular system. This review provides a comprehensive analysis of AKAPs’ involvement in the pathogenesis of cardiovascular diseases, emphasizing their key function in coordinating diverse signaling molecules, directing them to specific cellular microdomains, and minimizing signal interference. Disruptions in these interactions are linked to several cardiovascular disorders, such as cardiac hypertrophy, myocardial apoptosis, heart failure, arrhythmias, dysfunction in myocardial contraction and relaxation, and hypertension. Our goal was to explore the therapeutic potential of targeting the AKAP signaling pathway and offer new perspectives for the development and application of cardiovascular drugs that modulate AKAP signaling complexes. |
| format | Article |
| id | doaj-art-0b11e5fbceaf402cbba3266be1d77802 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-0b11e5fbceaf402cbba3266be1d778022025-08-20T03:31:23ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.16115831611583The role of A-kinase anchoring proteins in cardiovascular diseases and recent advancesXu Zhang0Xu Zhang1Feng Zhu2Zhaoqiang Xiao3Hegui Wang4Department of Cardiology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Cardiology, Liyang Branch Hospital, The First Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Surgery, Fengcheng Hospital of Fengxian District, Shanghai, ChinaDepartment of Cardiology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, ChinaCardiovascular diseases are a major global health concern, leading to high morbidity, mortality, and disability rates. Scaffold proteins, particularly A-kinase anchoring proteins (AKAPs), play a crucial role in signal transduction within the cardiovascular system. This review provides a comprehensive analysis of AKAPs’ involvement in the pathogenesis of cardiovascular diseases, emphasizing their key function in coordinating diverse signaling molecules, directing them to specific cellular microdomains, and minimizing signal interference. Disruptions in these interactions are linked to several cardiovascular disorders, such as cardiac hypertrophy, myocardial apoptosis, heart failure, arrhythmias, dysfunction in myocardial contraction and relaxation, and hypertension. Our goal was to explore the therapeutic potential of targeting the AKAP signaling pathway and offer new perspectives for the development and application of cardiovascular drugs that modulate AKAP signaling complexes.https://www.frontiersin.org/articles/10.3389/fcell.2025.1611583/fullA-kinase anchoring proteinsscaffold proteinscellular microdomainscardiovascular diseasescardiovascular drugs |
| spellingShingle | Xu Zhang Xu Zhang Feng Zhu Zhaoqiang Xiao Hegui Wang The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances Frontiers in Cell and Developmental Biology A-kinase anchoring proteins scaffold proteins cellular microdomains cardiovascular diseases cardiovascular drugs |
| title | The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances |
| title_full | The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances |
| title_fullStr | The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances |
| title_full_unstemmed | The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances |
| title_short | The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances |
| title_sort | role of a kinase anchoring proteins in cardiovascular diseases and recent advances |
| topic | A-kinase anchoring proteins scaffold proteins cellular microdomains cardiovascular diseases cardiovascular drugs |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1611583/full |
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