The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris
Objectives:We aimed to explore the potential role of omega-3 (ω-3) fatty acids on acne vulgaris by modulating gut microbiota.Materials and Methods:We randomly divided the untreated acne patients into two groups with or without ω-3 fatty acids intervention for 12 weeks. The Sprague Dawley (SD) rats w...
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2023.2299107 |
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| author | Yaxin Huang Fuming Liu Jindong Lai Shiyu Jiang Xiaoqi Tan Lingna Chen Yong Xu Xia Xiong Yongqiong Deng |
| author_facet | Yaxin Huang Fuming Liu Jindong Lai Shiyu Jiang Xiaoqi Tan Lingna Chen Yong Xu Xia Xiong Yongqiong Deng |
| author_sort | Yaxin Huang |
| collection | DOAJ |
| description | Objectives:We aimed to explore the potential role of omega-3 (ω-3) fatty acids on acne vulgaris by modulating gut microbiota.Materials and Methods:We randomly divided the untreated acne patients into two groups with or without ω-3 fatty acids intervention for 12 weeks. The Sprague Dawley (SD) rats with acne model were given isotretinoin, ω-3 fatty acids or their combination respectively. Then the colonic contents samples of the drug intervention SD rats were transferred to the pseudo sterile rats with acne model. The severity of the disease was assessed by the Global Acne Grading System (GAGS) score of the patients, and the swelling rate of auricle and the pathological section of the rat with acne model. The 16S rDNA gene sequencing was performed to detect the alteration of the gut microbiota.Results:ω-3 fatty acids could increase the diversity of the gut microbiota and regulate the flora structure positively both in the patients and rats, increase the abundance of butyric acid producing bacteria and GAGS score in the patients, and alleviate the inflammation and comedones of rats.Conclusion:Supplementation of ω-3 fatty acids could alleviate the inflammation of acne vulgaris by increasing the abundance of butyric acid producing bacteria. |
| format | Article |
| id | doaj-art-0b0a7dcbaf31494baa8959c8febf9b05 |
| institution | OA Journals |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-0b0a7dcbaf31494baa8959c8febf9b052025-08-20T01:58:20ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532024-12-0135110.1080/09546634.2023.2299107The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgarisYaxin Huang0Fuming Liu1Jindong Lai2Shiyu Jiang3Xiaoqi Tan4Lingna Chen5Yong Xu6Xia Xiong7Yongqiong Deng8Department of Dermatology & STD, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Dermatology & STD, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Dermatology, Suining First People's Hospital, Suining, Sichuan, ChinaDepartment of Dermatology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, ChinaDepartment of Dermatology & STD, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Dermatology & STD, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Dermatology & STD, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Dermatology & STD, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaObjectives:We aimed to explore the potential role of omega-3 (ω-3) fatty acids on acne vulgaris by modulating gut microbiota.Materials and Methods:We randomly divided the untreated acne patients into two groups with or without ω-3 fatty acids intervention for 12 weeks. The Sprague Dawley (SD) rats with acne model were given isotretinoin, ω-3 fatty acids or their combination respectively. Then the colonic contents samples of the drug intervention SD rats were transferred to the pseudo sterile rats with acne model. The severity of the disease was assessed by the Global Acne Grading System (GAGS) score of the patients, and the swelling rate of auricle and the pathological section of the rat with acne model. The 16S rDNA gene sequencing was performed to detect the alteration of the gut microbiota.Results:ω-3 fatty acids could increase the diversity of the gut microbiota and regulate the flora structure positively both in the patients and rats, increase the abundance of butyric acid producing bacteria and GAGS score in the patients, and alleviate the inflammation and comedones of rats.Conclusion:Supplementation of ω-3 fatty acids could alleviate the inflammation of acne vulgaris by increasing the abundance of butyric acid producing bacteria.https://www.tandfonline.com/doi/10.1080/09546634.2023.2299107Acne vulgarisω-3 fatty acidsgut microbiotadietThis study was registered with the ISRCTN Registry of Clinical Trials websiteISRCTN31758284 (https://doi.org/10.1186/ISRCTN31758284) |
| spellingShingle | Yaxin Huang Fuming Liu Jindong Lai Shiyu Jiang Xiaoqi Tan Lingna Chen Yong Xu Xia Xiong Yongqiong Deng The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris Journal of Dermatological Treatment Acne vulgaris ω-3 fatty acids gut microbiota diet This study was registered with the ISRCTN Registry of Clinical Trials website ISRCTN31758284 (https://doi.org/10.1186/ISRCTN31758284) |
| title | The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris |
| title_full | The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris |
| title_fullStr | The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris |
| title_full_unstemmed | The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris |
| title_short | The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris |
| title_sort | adjuvant treatment role of ω 3 fatty acids by regulating gut microbiota positively in the acne vulgaris |
| topic | Acne vulgaris ω-3 fatty acids gut microbiota diet This study was registered with the ISRCTN Registry of Clinical Trials website ISRCTN31758284 (https://doi.org/10.1186/ISRCTN31758284) |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2023.2299107 |
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