Auditory decision-making deficits after permanent noise-induced hearing loss
Abstract Loud noise exposure is one of the leading causes of permanent hearing loss. Individuals with noise-induced hearing loss (NIHL) suffer from speech comprehension deficits and experience impairments to cognitive functions such as attention and decision-making. Here, we investigate the specific...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-83374-8 |
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| author | Madeline P. Berns Genesis M. Nunez Xingeng Zhang Anindita Chavan Klavdia Zemlianova Todd M. Mowery Justin D. Yao |
| author_facet | Madeline P. Berns Genesis M. Nunez Xingeng Zhang Anindita Chavan Klavdia Zemlianova Todd M. Mowery Justin D. Yao |
| author_sort | Madeline P. Berns |
| collection | DOAJ |
| description | Abstract Loud noise exposure is one of the leading causes of permanent hearing loss. Individuals with noise-induced hearing loss (NIHL) suffer from speech comprehension deficits and experience impairments to cognitive functions such as attention and decision-making. Here, we investigate the specific underlying cognitive processes during auditory perceptual decision-making that are impacted by NIHL. Gerbils were trained to perform an auditory decision-making task that involves discriminating between slow and fast presentation rates of amplitude-modulated (AM) noise. Decision-making task performance was assessed across pre- versus post-NIHL sessions within the same gerbils. A single exposure session (2 h) to loud broadband noise (120 dB SPL) produced permanent NIHL with elevated threshold shifts in auditory brainstem responses (ABRs). Following NIHL, decision-making task performance was tested at sensation levels comparable to those prior to noise exposure in all animals. Our findings demonstrate NIHL diminished perceptual acuity, reduced attentional focus, altered choice bias, and slowed down evidence accumulation speed. Finally, video-tracking analysis of motor behavior during task performance demonstrates that NIHL can impact sensory-guided decision-based motor execution. Together, these results suggest that NIHL impairs the sensory, cognitive, and motor factors that support auditory decision-making. |
| format | Article |
| id | doaj-art-0b04e0ff63a847569ca72ff3ec69a6b1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-0b04e0ff63a847569ca72ff3ec69a6b12025-01-19T12:18:09ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-83374-8Auditory decision-making deficits after permanent noise-induced hearing lossMadeline P. Berns0Genesis M. Nunez1Xingeng Zhang2Anindita Chavan3Klavdia Zemlianova4Todd M. Mowery5Justin D. Yao6Department of Psychology – Behavioral and Systems Neuroscience, Rutgers, The State University of New JerseyBrain Health Institute, Rutgers, The State University of New Jersey, Nelson Biological Laboratory D418Brain Health Institute, Rutgers, The State University of New Jersey, Nelson Biological Laboratory D418Brain Health Institute, Rutgers, The State University of New Jersey, Nelson Biological Laboratory D418Zuckerman Mind Brain Behavior Institute, Columbia UniversityDepartment of Otolaryngology – Head and Neck Surgery, Rutgers Robert Wood Johnson Medical SchoolDepartment of Otolaryngology – Head and Neck Surgery, Rutgers Robert Wood Johnson Medical SchoolAbstract Loud noise exposure is one of the leading causes of permanent hearing loss. Individuals with noise-induced hearing loss (NIHL) suffer from speech comprehension deficits and experience impairments to cognitive functions such as attention and decision-making. Here, we investigate the specific underlying cognitive processes during auditory perceptual decision-making that are impacted by NIHL. Gerbils were trained to perform an auditory decision-making task that involves discriminating between slow and fast presentation rates of amplitude-modulated (AM) noise. Decision-making task performance was assessed across pre- versus post-NIHL sessions within the same gerbils. A single exposure session (2 h) to loud broadband noise (120 dB SPL) produced permanent NIHL with elevated threshold shifts in auditory brainstem responses (ABRs). Following NIHL, decision-making task performance was tested at sensation levels comparable to those prior to noise exposure in all animals. Our findings demonstrate NIHL diminished perceptual acuity, reduced attentional focus, altered choice bias, and slowed down evidence accumulation speed. Finally, video-tracking analysis of motor behavior during task performance demonstrates that NIHL can impact sensory-guided decision-based motor execution. Together, these results suggest that NIHL impairs the sensory, cognitive, and motor factors that support auditory decision-making.https://doi.org/10.1038/s41598-024-83374-8Auditory decision-makingNoise-induced hearing lossAuditory brainstem responseDrift–diffusion modelEvidence accumulation |
| spellingShingle | Madeline P. Berns Genesis M. Nunez Xingeng Zhang Anindita Chavan Klavdia Zemlianova Todd M. Mowery Justin D. Yao Auditory decision-making deficits after permanent noise-induced hearing loss Scientific Reports Auditory decision-making Noise-induced hearing loss Auditory brainstem response Drift–diffusion model Evidence accumulation |
| title | Auditory decision-making deficits after permanent noise-induced hearing loss |
| title_full | Auditory decision-making deficits after permanent noise-induced hearing loss |
| title_fullStr | Auditory decision-making deficits after permanent noise-induced hearing loss |
| title_full_unstemmed | Auditory decision-making deficits after permanent noise-induced hearing loss |
| title_short | Auditory decision-making deficits after permanent noise-induced hearing loss |
| title_sort | auditory decision making deficits after permanent noise induced hearing loss |
| topic | Auditory decision-making Noise-induced hearing loss Auditory brainstem response Drift–diffusion model Evidence accumulation |
| url | https://doi.org/10.1038/s41598-024-83374-8 |
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