General method for carbon–heteroatom cross-coupling reactions via semiheterogeneous red-light metallaphotocatalysis
Abstract Combining transition-metal catalysis with photocatalysis has emerged as a valuable, complementary approach for achieving carbon–heteroatom cross-coupling reactions. However, the need to use blue or high-energy near-UV light leads to problems with scalability, chemoselectivity, and catalyst...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61812-z |
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| author | Geyang Song Wei Zhang Jiameng Song Qi Li Yuyu Feng Hongyu Liang Tengfei Kang Jianyang Dong Gang Li Juan Fan Xue-Peng Zhang Quan Gu Chao Wang Dong Xue |
| author_facet | Geyang Song Wei Zhang Jiameng Song Qi Li Yuyu Feng Hongyu Liang Tengfei Kang Jianyang Dong Gang Li Juan Fan Xue-Peng Zhang Quan Gu Chao Wang Dong Xue |
| author_sort | Geyang Song |
| collection | DOAJ |
| description | Abstract Combining transition-metal catalysis with photocatalysis has emerged as a valuable, complementary approach for achieving carbon–heteroatom cross-coupling reactions. However, the need to use blue or high-energy near-UV light leads to problems with scalability, chemoselectivity, and catalyst deactivation, which have limited the synthetic applications of this combination. Herein, we report a method for red-light-driven nickel-catalyzed cross-coupling reactions of aryl halides with 11 different types of nucleophiles using a polymeric carbon nitride (CN-OA-m) as a photocatalyst. This semiheterogeneous catalyst system enabled the formation of four different types of carbon–heteroatom bonds (C–N, C–O, C–S, and C–Se) with a wide range of substrates (more than 200 examples) with yields up to 94%. Moreover, the photocatalyst is easily recovered and recycled, which makes it a promising new tool for the development of other reactions involving red-light metallaphotoredox catalysis. |
| format | Article |
| id | doaj-art-0b040a3941d64de69f0bebe05ffc1fff |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-0b040a3941d64de69f0bebe05ffc1fff2025-08-20T03:05:10ZengNature PortfolioNature Communications2041-17232025-07-0116111510.1038/s41467-025-61812-zGeneral method for carbon–heteroatom cross-coupling reactions via semiheterogeneous red-light metallaphotocatalysisGeyang Song0Wei Zhang1Jiameng Song2Qi Li3Yuyu Feng4Hongyu Liang5Tengfei Kang6Jianyang Dong7Gang Li8Juan Fan9Xue-Peng Zhang10Quan Gu11Chao Wang12Dong Xue13Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityKey Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal UniversityAbstract Combining transition-metal catalysis with photocatalysis has emerged as a valuable, complementary approach for achieving carbon–heteroatom cross-coupling reactions. However, the need to use blue or high-energy near-UV light leads to problems with scalability, chemoselectivity, and catalyst deactivation, which have limited the synthetic applications of this combination. Herein, we report a method for red-light-driven nickel-catalyzed cross-coupling reactions of aryl halides with 11 different types of nucleophiles using a polymeric carbon nitride (CN-OA-m) as a photocatalyst. This semiheterogeneous catalyst system enabled the formation of four different types of carbon–heteroatom bonds (C–N, C–O, C–S, and C–Se) with a wide range of substrates (more than 200 examples) with yields up to 94%. Moreover, the photocatalyst is easily recovered and recycled, which makes it a promising new tool for the development of other reactions involving red-light metallaphotoredox catalysis.https://doi.org/10.1038/s41467-025-61812-z |
| spellingShingle | Geyang Song Wei Zhang Jiameng Song Qi Li Yuyu Feng Hongyu Liang Tengfei Kang Jianyang Dong Gang Li Juan Fan Xue-Peng Zhang Quan Gu Chao Wang Dong Xue General method for carbon–heteroatom cross-coupling reactions via semiheterogeneous red-light metallaphotocatalysis Nature Communications |
| title | General method for carbon–heteroatom cross-coupling reactions via semiheterogeneous red-light metallaphotocatalysis |
| title_full | General method for carbon–heteroatom cross-coupling reactions via semiheterogeneous red-light metallaphotocatalysis |
| title_fullStr | General method for carbon–heteroatom cross-coupling reactions via semiheterogeneous red-light metallaphotocatalysis |
| title_full_unstemmed | General method for carbon–heteroatom cross-coupling reactions via semiheterogeneous red-light metallaphotocatalysis |
| title_short | General method for carbon–heteroatom cross-coupling reactions via semiheterogeneous red-light metallaphotocatalysis |
| title_sort | general method for carbon heteroatom cross coupling reactions via semiheterogeneous red light metallaphotocatalysis |
| url | https://doi.org/10.1038/s41467-025-61812-z |
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