The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in rats
Background: Piroxicam, a nonsteroidal antiinflammatory drug, is commonly used to induce inflammation in experimental models of inflammatory bowel disease (IBD). Piroxicam can modulate the immune system and disrupt the mucosal barrier, leading to increased production of reactive oxygen species. Aim...
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Tripoli University
2025-03-01
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| Series: | Open Veterinary Journal |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=233909 |
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| author | Maya Nurwartanti Yunita Hani Plumeriastuti Bodhi Agustono Moch. Ilham Riza Fahlefi Aprilia Rizki Fadilla Ragil Ayu Pangastutie Shelly Oktania Nurvita Sari Muhammad Fikri Syamsuri Muhammad Alivio Putra Fajar Reina Puspita Rahmaniar Md. Aliar Rahman |
| author_facet | Maya Nurwartanti Yunita Hani Plumeriastuti Bodhi Agustono Moch. Ilham Riza Fahlefi Aprilia Rizki Fadilla Ragil Ayu Pangastutie Shelly Oktania Nurvita Sari Muhammad Fikri Syamsuri Muhammad Alivio Putra Fajar Reina Puspita Rahmaniar Md. Aliar Rahman |
| author_sort | Maya Nurwartanti Yunita |
| collection | DOAJ |
| description | Background:
Piroxicam, a nonsteroidal antiinflammatory drug, is commonly used to induce inflammation in experimental models of inflammatory bowel disease (IBD). Piroxicam can modulate the immune system and disrupt the mucosal barrier, leading to increased production of reactive oxygen species.
Aim:
This study aimed to evaluate the effects of single-clove garlic (Allium sativum var. solo garlic) extract (SGE) on liver histopathological findings, superoxide dismutase (SOD), and malondialdehyde (MDA) levels in white rats (Rattus norvegicus) Wistar strain induced with piroxicam.
Methods:
The study used a completely randomized design with 30 male Wistar rats aged 2 months and weighing 150– 200 g. The rats were divided into five groups: negative control (C), receiving CMC-Na 0,5% only; positive control (T0), receiving 20 mg/kgBW piroxicam; and three treatment groups, receiving 20 mg/kgBW piroxicam combined with 75 mg/kgBW (T1), 100 mg/kgBW (T2), or 125 mg/kgBW (T3) of SGE. Piroxicam was administered orally to induce inflammation, followed by SGE treatment for 14 days. Liver histopathological images were measured for damage repair using the scoring method. Superoxide dismutase and malondialdehyde levels were measured using enzymelinked immunosorbent assay methods.
Results:
The results showed a significant increase in SOD levels (p < 0.05) in the treatment groups compared with the T0 (20 mg/kgBW piroxicam), with the T3 (125 mg/kgBW piroxicam) showing the most significant effect. Additionally, MDA levels were significantly decreased (p < 0.05) in all treatment groups, indicating a reduction in oxidative damage. Statistical analysis revealed a dose-dependent relationship between garlic extract administration and improvement in liver histopathological findings and oxidative stress markers.
Conclusion:
SGE is a potent antioxidant that reduces oxidative stress in a piroxicam-induced IBD model and contributes to good health. Further studies are needed to explore the molecular mechanisms underlying these effects and to optimize the therapeutic potential of IBD. [Open Vet J 2025; 15(3.000): 1349-1357] |
| format | Article |
| id | doaj-art-0b02de4abc304e3b83595ea92b8df2ab |
| institution | OA Journals |
| issn | 2226-4485 2218-6050 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj-art-0b02de4abc304e3b83595ea92b8df2ab2025-08-20T02:16:01ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502025-03-011531349135710.5455/OVJ.2025.v15.i3.26233909The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in ratsMaya Nurwartanti Yunita0Hani Plumeriastuti1Bodhi Agustono2Moch. Ilham Riza Fahlefi3Aprilia Rizki Fadilla4Ragil Ayu Pangastutie5Shelly Oktania Nurvita Sari6Muhammad Fikri Syamsuri7Muhammad Alivio Putra Fajar8Reina Puspita Rahmaniar9Md. Aliar Rahman10Veterinary Pathology Division, Faculty of Health, Medicine and Life Sciences, Universitas Airlangga, Surabaya 60115, Indonesia. Department of Veterinary Science, Division of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia Veterinary Medicine, Faculty of Health, Medicine and Life Sciences, Universitas Airlangga, Indonesia. Veterinary Medicine, Faculty of Health, Medicine and Life Sciences, Universitas Airlangga, Indonesia. Veterinary Medicine, Faculty of Health, Medicine and Life Sciences, Universitas Airlangga, Indonesia. Veterinary Medicine, Faculty of Health, Medicine and Life Sciences, Universitas Airlangga, Indonesia. Veterinary Medicine, Faculty of Health, Medicine and Life Sciences, Universitas Airlangga, Indonesia. Veterinary Medicine, Faculty of Health, Medicine and Life Sciences, Universitas Airlangga, Indonesia. Veterinary Medicine, Faculty of Health, Medicine and Life Sciences, Universitas Airlangga, Indonesia. Department of Microbiology, Faculty of Veterinary Medicine, Wijaya Kusuma University, Surabaya, Indonesia Bangladesh Agricultural UniversityBackground: Piroxicam, a nonsteroidal antiinflammatory drug, is commonly used to induce inflammation in experimental models of inflammatory bowel disease (IBD). Piroxicam can modulate the immune system and disrupt the mucosal barrier, leading to increased production of reactive oxygen species. Aim: This study aimed to evaluate the effects of single-clove garlic (Allium sativum var. solo garlic) extract (SGE) on liver histopathological findings, superoxide dismutase (SOD), and malondialdehyde (MDA) levels in white rats (Rattus norvegicus) Wistar strain induced with piroxicam. Methods: The study used a completely randomized design with 30 male Wistar rats aged 2 months and weighing 150– 200 g. The rats were divided into five groups: negative control (C), receiving CMC-Na 0,5% only; positive control (T0), receiving 20 mg/kgBW piroxicam; and three treatment groups, receiving 20 mg/kgBW piroxicam combined with 75 mg/kgBW (T1), 100 mg/kgBW (T2), or 125 mg/kgBW (T3) of SGE. Piroxicam was administered orally to induce inflammation, followed by SGE treatment for 14 days. Liver histopathological images were measured for damage repair using the scoring method. Superoxide dismutase and malondialdehyde levels were measured using enzymelinked immunosorbent assay methods. Results: The results showed a significant increase in SOD levels (p < 0.05) in the treatment groups compared with the T0 (20 mg/kgBW piroxicam), with the T3 (125 mg/kgBW piroxicam) showing the most significant effect. Additionally, MDA levels were significantly decreased (p < 0.05) in all treatment groups, indicating a reduction in oxidative damage. Statistical analysis revealed a dose-dependent relationship between garlic extract administration and improvement in liver histopathological findings and oxidative stress markers. Conclusion: SGE is a potent antioxidant that reduces oxidative stress in a piroxicam-induced IBD model and contributes to good health. Further studies are needed to explore the molecular mechanisms underlying these effects and to optimize the therapeutic potential of IBD. [Open Vet J 2025; 15(3.000): 1349-1357]http://www.ejmanager.com/fulltextpdf.php?mno=233909good healthliver histopathologicalmdapiroxicamsingle garlicsod |
| spellingShingle | Maya Nurwartanti Yunita Hani Plumeriastuti Bodhi Agustono Moch. Ilham Riza Fahlefi Aprilia Rizki Fadilla Ragil Ayu Pangastutie Shelly Oktania Nurvita Sari Muhammad Fikri Syamsuri Muhammad Alivio Putra Fajar Reina Puspita Rahmaniar Md. Aliar Rahman The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in rats Open Veterinary Journal good health liver histopathological mda piroxicam single garlic sod |
| title | The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in rats |
| title_full | The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in rats |
| title_fullStr | The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in rats |
| title_full_unstemmed | The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in rats |
| title_short | The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in rats |
| title_sort | protective effects of garlic allium sativum var solo garlic extract mitigates piroxicam induced liver damage and oxidative stress in rats |
| topic | good health liver histopathological mda piroxicam single garlic sod |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=233909 |
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