Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011–2016
Abstract Organophosphate esters (OPEs) exposure has potentially harmful effects on human health. However, the evidence between OPEs and hyperuricemia is insufficient. We aimed to assess the association between OPEs metabolites and the prevalence of hyperuricemia. Multivariable logistic regression, w...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-96423-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850184043567513600 |
|---|---|
| author | Qiong Huang Wenbin Nan Siqi Li Baimei He Xu Cai Zhenyu Peng Chenlu Wu |
| author_facet | Qiong Huang Wenbin Nan Siqi Li Baimei He Xu Cai Zhenyu Peng Chenlu Wu |
| author_sort | Qiong Huang |
| collection | DOAJ |
| description | Abstract Organophosphate esters (OPEs) exposure has potentially harmful effects on human health. However, the evidence between OPEs and hyperuricemia is insufficient. We aimed to assess the association between OPEs metabolites and the prevalence of hyperuricemia. Multivariable logistic regression, weighted quantile regression (WQS) model, and Bayesian kernel machine regression (BKMR) models were used to investigate the association of OPEs metabolites with the risk of hyperuricemia. Mediation analysis was conducted to assess whether inflammation mediated the effects of OPEs on the prevalence of hyperuricemia. The multivariable logistics regression indicated that bis (1,3-dichloro-2-propyl) phosphate (BDCPP) and bis-2-chloroethyl phosphate (BCEP) were positively correlated with the risk of hyperuricemia. In WQS and BKMR analyses, OPEs mixtures presented a positive association with the risk of hyperuricemia, with BDCPP being the primary contributor. C-reactive protein (CRP) and monocytes were found to mediate the association between BDCPP and the risk of hyperuricemia prevalence, with 8.46% and 3.97% of the mediated proportion, respectively. Our study revealed that OPEs mixtures were positively correlated with the prevalence of hyperuricemia, with BDCPP identified as the most significant contributor. Inflammation was a potential mechanism mediating the effect of BDCPP exposure on the risk of hyperuricemia. |
| format | Article |
| id | doaj-art-0afe85ce7c504ceaa75acdb2d5968bc9 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0afe85ce7c504ceaa75acdb2d5968bc92025-08-20T02:17:09ZengNature PortfolioScientific Reports2045-23222025-04-0115111110.1038/s41598-025-96423-7Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011–2016Qiong Huang0Wenbin Nan1Siqi Li2Baimei He3Xu Cai4Zhenyu Peng5Chenlu Wu6Department of Metabolism and Endocrinology, Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, Second Xiangya Hospital, Central South UniversityDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South UniversityDepartment of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, Second Xiangya Hospital, Central South UniversityDepartment of Cardiology, Second Xiangya Hospital, Central South UniversityAbstract Organophosphate esters (OPEs) exposure has potentially harmful effects on human health. However, the evidence between OPEs and hyperuricemia is insufficient. We aimed to assess the association between OPEs metabolites and the prevalence of hyperuricemia. Multivariable logistic regression, weighted quantile regression (WQS) model, and Bayesian kernel machine regression (BKMR) models were used to investigate the association of OPEs metabolites with the risk of hyperuricemia. Mediation analysis was conducted to assess whether inflammation mediated the effects of OPEs on the prevalence of hyperuricemia. The multivariable logistics regression indicated that bis (1,3-dichloro-2-propyl) phosphate (BDCPP) and bis-2-chloroethyl phosphate (BCEP) were positively correlated with the risk of hyperuricemia. In WQS and BKMR analyses, OPEs mixtures presented a positive association with the risk of hyperuricemia, with BDCPP being the primary contributor. C-reactive protein (CRP) and monocytes were found to mediate the association between BDCPP and the risk of hyperuricemia prevalence, with 8.46% and 3.97% of the mediated proportion, respectively. Our study revealed that OPEs mixtures were positively correlated with the prevalence of hyperuricemia, with BDCPP identified as the most significant contributor. Inflammation was a potential mechanism mediating the effect of BDCPP exposure on the risk of hyperuricemia.https://doi.org/10.1038/s41598-025-96423-7HyperuricemiaOrganophosphate estersInflammationNHANESOPEs |
| spellingShingle | Qiong Huang Wenbin Nan Siqi Li Baimei He Xu Cai Zhenyu Peng Chenlu Wu Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011–2016 Scientific Reports Hyperuricemia Organophosphate esters Inflammation NHANES OPEs |
| title | Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011–2016 |
| title_full | Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011–2016 |
| title_fullStr | Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011–2016 |
| title_full_unstemmed | Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011–2016 |
| title_short | Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011–2016 |
| title_sort | association between organophosphate esters exposure and the prevalence of hyperuricemia in us adults from nhanes 2011 2016 |
| topic | Hyperuricemia Organophosphate esters Inflammation NHANES OPEs |
| url | https://doi.org/10.1038/s41598-025-96423-7 |
| work_keys_str_mv | AT qionghuang associationbetweenorganophosphateestersexposureandtheprevalenceofhyperuricemiainusadultsfromnhanes20112016 AT wenbinnan associationbetweenorganophosphateestersexposureandtheprevalenceofhyperuricemiainusadultsfromnhanes20112016 AT siqili associationbetweenorganophosphateestersexposureandtheprevalenceofhyperuricemiainusadultsfromnhanes20112016 AT baimeihe associationbetweenorganophosphateestersexposureandtheprevalenceofhyperuricemiainusadultsfromnhanes20112016 AT xucai associationbetweenorganophosphateestersexposureandtheprevalenceofhyperuricemiainusadultsfromnhanes20112016 AT zhenyupeng associationbetweenorganophosphateestersexposureandtheprevalenceofhyperuricemiainusadultsfromnhanes20112016 AT chenluwu associationbetweenorganophosphateestersexposureandtheprevalenceofhyperuricemiainusadultsfromnhanes20112016 |