Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination.

Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination.

Vaccination with radiation-attenuated sporozoites (RAS) can provide highly effective protection against malaria in both humans and mice. To extend understanding of malaria immunity and inform the development of future vaccines, we studied the protective response elicited by this vaccine in C57BL/6 m...

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Main Authors:	Maria N de Menezes, Zhengyu Ge, Anton Cozijnsen, Stephanie Gras, Patrick Bertolino, Irina Caminschi, Mireille H Lahoud, Katsuyuki Yui, Geoffrey I McFadden, Lynette Beattie, William R Heath, Daniel Fernandez-Ruiz
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-05-01
Series:	PLoS Pathogens
Online Access:	https://doi.org/10.1371/journal.ppat.1012731
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