Nature-inspired and medicinally relevant short peptides
Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered the cycle of creation, application, and destruction of large and short peptides to the benefit of the host...
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| Format: | Article |
| Language: | English |
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Open Exploration
2023-06-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100811/100811.pdf |
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| author | Maria G. Ciulla Monica Civera Sara Sattin Kamal Kumar |
| author_facet | Maria G. Ciulla Monica Civera Sara Sattin Kamal Kumar |
| author_sort | Maria G. Ciulla |
| collection | DOAJ |
| description | Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered the cycle of creation, application, and destruction of large and short peptides to the benefit of the host organism, organic and medicinal chemists have in their capacity and small steps, made big developments in the field of peptide synthesis as well as in developing them as therapeutics. In comparison to their big counterparts, i.e. proteins, short peptides encompass several advantages, from the ease of synthesis to their physico-chemical properties. However, the real challenge for in vivo application of therapeutic peptides is to overcome their low plasma availability and their fast enzymatic degradation. This review briefly covers the relevant areas of medicinally important short peptides and the recent developments made to turn these peptides into therapeutics. Also presented in this article are important efforts and strategies used to overcome some of the inherent limitations of peptidic molecules and thereby facilitate their progression in the clinical phases towards approved drugs. |
| format | Article |
| id | doaj-art-0afa40f331004d849f3e814e75a22b63 |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-0afa40f331004d849f3e814e75a22b632025-02-08T04:48:16ZengOpen ExplorationExploration of Drug Science2836-76772023-06-011314017110.37349/eds.2023.00011Nature-inspired and medicinally relevant short peptidesMaria G. Ciulla0https://orcid.org/0000-0001-8738-1712Monica Civera1https://orcid.org/0000-0001-5171-1062Sara Sattin2https://orcid.org/0000-0002-5558-3915Kamal Kumar3https://orcid.org/0000-0003-3593-8421Department of Chemistry, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Chemistry, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Chemistry, Università degli Studi di Milano, 20133 Milan, ItalyAicuris Anti-infective Cures AG, 42117 Wuppertal, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, GermanyPeptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered the cycle of creation, application, and destruction of large and short peptides to the benefit of the host organism, organic and medicinal chemists have in their capacity and small steps, made big developments in the field of peptide synthesis as well as in developing them as therapeutics. In comparison to their big counterparts, i.e. proteins, short peptides encompass several advantages, from the ease of synthesis to their physico-chemical properties. However, the real challenge for in vivo application of therapeutic peptides is to overcome their low plasma availability and their fast enzymatic degradation. This review briefly covers the relevant areas of medicinally important short peptides and the recent developments made to turn these peptides into therapeutics. Also presented in this article are important efforts and strategies used to overcome some of the inherent limitations of peptidic molecules and thereby facilitate their progression in the clinical phases towards approved drugs.https://www.explorationpub.com/uploads/Article/A100811/100811.pdfshort peptidespeptide drugspeptide stabilitypharmaceutical properties |
| spellingShingle | Maria G. Ciulla Monica Civera Sara Sattin Kamal Kumar Nature-inspired and medicinally relevant short peptides Exploration of Drug Science short peptides peptide drugs peptide stability pharmaceutical properties |
| title | Nature-inspired and medicinally relevant short peptides |
| title_full | Nature-inspired and medicinally relevant short peptides |
| title_fullStr | Nature-inspired and medicinally relevant short peptides |
| title_full_unstemmed | Nature-inspired and medicinally relevant short peptides |
| title_short | Nature-inspired and medicinally relevant short peptides |
| title_sort | nature inspired and medicinally relevant short peptides |
| topic | short peptides peptide drugs peptide stability pharmaceutical properties |
| url | https://www.explorationpub.com/uploads/Article/A100811/100811.pdf |
| work_keys_str_mv | AT mariagciulla natureinspiredandmedicinallyrelevantshortpeptides AT monicacivera natureinspiredandmedicinallyrelevantshortpeptides AT sarasattin natureinspiredandmedicinallyrelevantshortpeptides AT kamalkumar natureinspiredandmedicinallyrelevantshortpeptides |