Personalised selection of medication for newly diagnosed adult epilepsy: study protocol of a first-in-class, double-blind, randomised controlled trial

Personalised selection of medication for newly diagnosed adult epilepsy: study protocol of a first-in-class, double-blind, randomised controlled trial

Introduction Selection of antiseizure medications (ASMs) for newly diagnosed epilepsy remains largely a trial-and-error process. We have developed a machine learning (ML) model using retrospective data collected from five international cohorts that predicts response to different ASMs as the initial...

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Main Authors: Mark Howard, Wendyl D’Souza, Emma Foster, Patrick Carney, Zanfina Ademi, Patrick Kwan, David N Vaughan, James Lee, Clare Stapleton, Zongyuan Ge, Zhibin Chen, Natasha A Lannin, Udaya Seneviratne, Robert Sparrow, Piero Perucca, Armin Nikpour, Chong Wong, John-Paul Nicolo, Michelle Kiley, Terence O’Brien, Jacqui-Lyn Saw, Dean Jones, David Reutens, Sandra Reeder, Richard Shek-kwan Chang, Ernest Somerville, Tania Farrar, Daniel Thom, Lata Vadlamudi
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/4/e086607.full
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