Advances in cardioprotective strategies: Bridging traditional pharmacotherapy and regenerative medicine
Cardiovascular diseases (CVDs) remain the leading global cause of death and disability, underscoring the need for improved therapies. Key emerging strategies include pharmacological cardioprotection, cell-based therapies and the use of exosomes as therapeutic agents and biomarkers. Aim of this study...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2025-01-01
|
| Series: | Scripta Medica |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2025/2490-33292503521H.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849409085288480768 |
|---|---|
| author | Hladkykh Fedir V. Matvieienko Mariia M. Liadova Tetiana I Karafulidi Olha V. Komorovsky Roman R. |
| author_facet | Hladkykh Fedir V. Matvieienko Mariia M. Liadova Tetiana I Karafulidi Olha V. Komorovsky Roman R. |
| author_sort | Hladkykh Fedir V. |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) remain the leading global cause of death and disability, underscoring the need for improved therapies. Key emerging strategies include pharmacological cardioprotection, cell-based therapies and the use of exosomes as therapeutic agents and biomarkers. Aim of this study was to characterise contemporary approaches to cardioprotection in CVDs, including pharmacological agents, cell-based therapies and exosome-based strategies, based on an analysis of evidence-based data. A systematic literature search was performed using databases including PubMed, Clinical Key (Elsevier), Cochrane Library, eBook Business Collection and Google Scholar. Keywords included cardioprotection, exosomes, cell-based therapies and pharmacological approaches. Article selection followed evidence-based medicine principles and the PRISMA guidelines. Current cardioprotective strategies include both traditional pharmacological agents, such as b-blockers, calcium channel blockers, ACE inhibitors, statins and nitrates, as well as innovative approaches like cell-based therapies and the use of exosomes. The advantages and limitations of cell therapy were analysed, including challenges related to low cell survival, failure of differentiation and the risk of arrhythmias. The role of exosomes and microvesicles as promising markers of cardiovascular injury and potential therapeutic agents was also explored. Combining pharmacological, cell-based and exosome-based strategies offers new prospects for cardioprotection in CVDs. Further research is required to optimise the clinical use of cell therapies and to confirm the efficacy of exosome-based interventions. |
| format | Article |
| id | doaj-art-0aef2be5b63f4f0e9d7d63fd9127e835 |
| institution | Kabale University |
| issn | 2490-3329 2303-7954 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj-art-0aef2be5b63f4f0e9d7d63fd9127e8352025-08-20T03:35:37ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542025-01-0156352153510.5937/scriptamed56-587192490-33292503521HAdvances in cardioprotective strategies: Bridging traditional pharmacotherapy and regenerative medicineHladkykh Fedir V.0https://orcid.org/0000-0001-7924-4048Matvieienko Mariia M.1https://orcid.org/0000-0002-0388-138XLiadova Tetiana I2https://orcid.org/0000-0002-5892-2599Karafulidi Olha V.3https://orcid.org/0009-0008-4669-6708Komorovsky Roman R.4https://orcid.org/0000-0002-0288-4132Grigoriev Institute for Medical Radiology and Oncology, Radiation Pathology and Palliative Medicine Group, Radiology Department, Kharkiv, UkraineV. N. Karazin Kharkiv National University, Department of General Surgery, Anaesthesiology and Palliative Medicine, Kharkiv, UkraineV. N. Karazin Kharkiv National University, Department of Infectious Diseases and Clinical Immunology, Kharkiv, UkraineO.I. Meshchaninov Kharkiv City Emergency Clinical Hospital, Anaesthesiology and Intensive Care Unit, Kharkiv, UkraineIvan Horbachevsky Ternopil National Medical University, Department of Internal Medicine II, Ternopil, UkraineCardiovascular diseases (CVDs) remain the leading global cause of death and disability, underscoring the need for improved therapies. Key emerging strategies include pharmacological cardioprotection, cell-based therapies and the use of exosomes as therapeutic agents and biomarkers. Aim of this study was to characterise contemporary approaches to cardioprotection in CVDs, including pharmacological agents, cell-based therapies and exosome-based strategies, based on an analysis of evidence-based data. A systematic literature search was performed using databases including PubMed, Clinical Key (Elsevier), Cochrane Library, eBook Business Collection and Google Scholar. Keywords included cardioprotection, exosomes, cell-based therapies and pharmacological approaches. Article selection followed evidence-based medicine principles and the PRISMA guidelines. Current cardioprotective strategies include both traditional pharmacological agents, such as b-blockers, calcium channel blockers, ACE inhibitors, statins and nitrates, as well as innovative approaches like cell-based therapies and the use of exosomes. The advantages and limitations of cell therapy were analysed, including challenges related to low cell survival, failure of differentiation and the risk of arrhythmias. The role of exosomes and microvesicles as promising markers of cardiovascular injury and potential therapeutic agents was also explored. Combining pharmacological, cell-based and exosome-based strategies offers new prospects for cardioprotection in CVDs. Further research is required to optimise the clinical use of cell therapies and to confirm the efficacy of exosome-based interventions.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2025/2490-33292503521H.pdfcardiovascular diseasesprevention and control, cardiacexosomescell and tissue-based therapytherapeuticsischaemiaischaemic injuryregenerative medicineadrenergic beta-antagonistscalcium channel blockersmicrovesicles |
| spellingShingle | Hladkykh Fedir V. Matvieienko Mariia M. Liadova Tetiana I Karafulidi Olha V. Komorovsky Roman R. Advances in cardioprotective strategies: Bridging traditional pharmacotherapy and regenerative medicine Scripta Medica cardiovascular diseases prevention and control, cardiac exosomes cell and tissue-based therapy therapeutics ischaemia ischaemic injury regenerative medicine adrenergic beta-antagonists calcium channel blockers microvesicles |
| title | Advances in cardioprotective strategies: Bridging traditional pharmacotherapy and regenerative medicine |
| title_full | Advances in cardioprotective strategies: Bridging traditional pharmacotherapy and regenerative medicine |
| title_fullStr | Advances in cardioprotective strategies: Bridging traditional pharmacotherapy and regenerative medicine |
| title_full_unstemmed | Advances in cardioprotective strategies: Bridging traditional pharmacotherapy and regenerative medicine |
| title_short | Advances in cardioprotective strategies: Bridging traditional pharmacotherapy and regenerative medicine |
| title_sort | advances in cardioprotective strategies bridging traditional pharmacotherapy and regenerative medicine |
| topic | cardiovascular diseases prevention and control, cardiac exosomes cell and tissue-based therapy therapeutics ischaemia ischaemic injury regenerative medicine adrenergic beta-antagonists calcium channel blockers microvesicles |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2025/2490-33292503521H.pdf |
| work_keys_str_mv | AT hladkykhfedirv advancesincardioprotectivestrategiesbridgingtraditionalpharmacotherapyandregenerativemedicine AT matvieienkomariiam advancesincardioprotectivestrategiesbridgingtraditionalpharmacotherapyandregenerativemedicine AT liadovatetianai advancesincardioprotectivestrategiesbridgingtraditionalpharmacotherapyandregenerativemedicine AT karafulidiolhav advancesincardioprotectivestrategiesbridgingtraditionalpharmacotherapyandregenerativemedicine AT komorovskyromanr advancesincardioprotectivestrategiesbridgingtraditionalpharmacotherapyandregenerativemedicine |