The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual Literature
Anabolic-Androgenic Steroids (AAS), despite their therapeutic applications in the management of selected medical conditions, are increasingly being misused for non-medical purposes—particularly among bodybuilders and individuals seeking to enhance their physique. This review article examines the im...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-05-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/60236 |
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| author | Julia Marcinkowska Mateusz Szymon Muras Tomasz Lorenc Maciej Michalik Krzysztof Marcinkowski Jakub Mikszta Natalia Mikszta |
| author_facet | Julia Marcinkowska Mateusz Szymon Muras Tomasz Lorenc Maciej Michalik Krzysztof Marcinkowski Jakub Mikszta Natalia Mikszta |
| author_sort | Julia Marcinkowska |
| collection | DOAJ |
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Anabolic-Androgenic Steroids (AAS), despite their therapeutic applications in the management of selected medical conditions, are increasingly being misused for non-medical purposes—particularly among bodybuilders and individuals seeking to enhance their physique. This review article examines the impact of chronic AAS administration on the functionality of selected human organs and physiological systems.
Based on current clinical and preclinical evidence, the biological mechanisms of AAS action are discussed, with particular emphasis on their affinity for androgen receptors and modulation of intracellular signaling pathways. The paper presents robust evidence of the adverse effects associated with AAS use, including cardiomyopathies, renal dysfunction, neuropsychiatric disorders (notably increased aggression and depressive symptoms), hepatotoxicity, and metabolic disturbances.
Special attention is given to the potential mechanisms underlying AAS-induced toxicity, as well as the reversibility of the observed pathological alterations. The findings underscore the necessity for intensified health education and systematic monitoring of individuals using AAS, due to the elevated risk of irreversible, multisystem complications.
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| format | Article |
| id | doaj-art-0aee9d35f0a047349f3e373263c9ca7e |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-0aee9d35f0a047349f3e373263c9ca7e2025-08-20T03:53:18ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-05-014110.12775/QS.2025.41.60236The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual LiteratureJulia Marcinkowska0https://orcid.org/0009-0005-7006-4303Mateusz Szymon Muras1https://orcid.org/0009-0005-1392-3773Tomasz Lorenc2https://orcid.org/0009-0008-9902-469XMaciej Michalik3https://orcid.org/0009-0009-7799-7252Krzysztof Marcinkowski4https://orcid.org/0009-0002-5759-7285Jakub Mikszta5https://orcid.org/0009-0000-4194-9915Natalia Mikszta6https://orcid.org/0009-0003-8444-7650Śląski Uniwersytet MedycznyŚląski Uniwersytet MedycznyŚląski Uniwersytet MedycznyŚląski Uniwersytet MedycznyŚląski Uniwersytet MedycznyUniwersytet OpolskiŚląski Uniwersytet Medyczny Anabolic-Androgenic Steroids (AAS), despite their therapeutic applications in the management of selected medical conditions, are increasingly being misused for non-medical purposes—particularly among bodybuilders and individuals seeking to enhance their physique. This review article examines the impact of chronic AAS administration on the functionality of selected human organs and physiological systems. Based on current clinical and preclinical evidence, the biological mechanisms of AAS action are discussed, with particular emphasis on their affinity for androgen receptors and modulation of intracellular signaling pathways. The paper presents robust evidence of the adverse effects associated with AAS use, including cardiomyopathies, renal dysfunction, neuropsychiatric disorders (notably increased aggression and depressive symptoms), hepatotoxicity, and metabolic disturbances. Special attention is given to the potential mechanisms underlying AAS-induced toxicity, as well as the reversibility of the observed pathological alterations. The findings underscore the necessity for intensified health education and systematic monitoring of individuals using AAS, due to the elevated risk of irreversible, multisystem complications. https://apcz.umk.pl/QS/article/view/60236anabolic androgenic steroidsdepressionleft ventricular dysfunctionacute kidney injury (AKI) |
| spellingShingle | Julia Marcinkowska Mateusz Szymon Muras Tomasz Lorenc Maciej Michalik Krzysztof Marcinkowski Jakub Mikszta Natalia Mikszta The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual Literature Quality in Sport anabolic androgenic steroids depression left ventricular dysfunction acute kidney injury (AKI) |
| title | The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual Literature |
| title_full | The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual Literature |
| title_fullStr | The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual Literature |
| title_full_unstemmed | The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual Literature |
| title_short | The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual Literature |
| title_sort | impact of anabolic androgenic steroids on organ failure in bodybuilders a review of actual literature |
| topic | anabolic androgenic steroids depression left ventricular dysfunction acute kidney injury (AKI) |
| url | https://apcz.umk.pl/QS/article/view/60236 |
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