Recent advances in film dosimetry for quality assurance in microbeam radiation therapy
Abstract Microbeam Radiation Therapy (MRT) is currently on the verge of entering the clinical phase, necessitating robust quality assurance (QA) with appropriate dosimeters to ensure patient safety. However, MRT dosimetry presents significant challenges due to its intrinsic characteristics, includin...
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-12449-x |
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| author | Sarvenaz Keshmiri Gaëtan Lemaire Adélie André Florian Thevenet Alexandre Ocadiz Nicolas Rosuel Benjamin Huffschmidt Yacine Bencheikh Mostafa Ghafooryan-Sangchooli Paolo Pellicioli Raphaël Serduc Jean-François Adam |
| author_facet | Sarvenaz Keshmiri Gaëtan Lemaire Adélie André Florian Thevenet Alexandre Ocadiz Nicolas Rosuel Benjamin Huffschmidt Yacine Bencheikh Mostafa Ghafooryan-Sangchooli Paolo Pellicioli Raphaël Serduc Jean-François Adam |
| author_sort | Sarvenaz Keshmiri |
| collection | DOAJ |
| description | Abstract Microbeam Radiation Therapy (MRT) is currently on the verge of entering the clinical phase, necessitating robust quality assurance (QA) with appropriate dosimeters to ensure patient safety. However, MRT dosimetry presents significant challenges due to its intrinsic characteristics, including steep dose gradients with alternating high and low dose regions—referred to as peaks and valleys (valley doses comprising only 5–7 $$\%$$ of peak doses)—micrometric resolution requirements, the use of low-to-medium energy X-rays and extremely high dose rates of up to 16 kGy/s. Currently, Gafchromic films are considered the gold standard for patient QA. Previous studies have reported discrepancies of 10–30 $$\%$$ between measured and calculated peak and valley doses. This study aimed to evaluate four types of films (EBT-3, EBT-XD, MD-V3, and HD-V2) to determine the most suitable option for MRT QA. To support dosimetric benchmarking, the microDiamond detector was used as the reference for MRT measurements, and the ionization chamber for broad beam reference dosimetry. Discrepancies were observed between calculated and film-measured peak and valley doses, and several hypotheses were proposed to explain these differences. Possible causes include simplifications in dose calculation engines, intrinsic limitations of the films, uncertainties in experimental setups, and variations in readout methods. The study suggests that MD-V3 may be the most suitable film for MRT dosimetry, offering a dynamic range that effectively covers both peak and valley doses. |
| format | Article |
| id | doaj-art-0aed1172bca64747b5bf5faf52f3c010 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
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| spelling | doaj-art-0aed1172bca64747b5bf5faf52f3c0102025-08-20T04:02:46ZengNature PortfolioScientific Reports2045-23222025-08-0115111310.1038/s41598-025-12449-xRecent advances in film dosimetry for quality assurance in microbeam radiation therapySarvenaz Keshmiri0Gaëtan Lemaire1Adélie André2Florian Thevenet3Alexandre Ocadiz4Nicolas Rosuel5Benjamin Huffschmidt6Yacine Bencheikh7Mostafa Ghafooryan-Sangchooli8Paolo Pellicioli9Raphaël Serduc10Jean-François Adam11Univ. Grenoble Alpes, INSERM, UA07 STROBEUniv. Grenoble Alpes, INSERM, UA07 STROBEUniv. Grenoble-Alpes, CNRS, Grenoble INP, LPSC UMR5821Univ. Grenoble Alpes, INSERM, UA07 STROBEUniv. Grenoble Alpes, INSERM, UA07 STROBEUniv. Grenoble Alpes, INSERM, UA07 STROBEUniv. Grenoble Alpes, INSERM, UA07 STROBEUniv. Grenoble Alpes, INSERM, UA07 STROBEUniv. Grenoble Alpes, INSERM, UA07 STROBEID17 Biomedical Beamline, ESRF—The European SynchrotronUniv. Grenoble Alpes, INSERM, UA07 STROBEUniv. Grenoble Alpes, INSERM, UA07 STROBEAbstract Microbeam Radiation Therapy (MRT) is currently on the verge of entering the clinical phase, necessitating robust quality assurance (QA) with appropriate dosimeters to ensure patient safety. However, MRT dosimetry presents significant challenges due to its intrinsic characteristics, including steep dose gradients with alternating high and low dose regions—referred to as peaks and valleys (valley doses comprising only 5–7 $$\%$$ of peak doses)—micrometric resolution requirements, the use of low-to-medium energy X-rays and extremely high dose rates of up to 16 kGy/s. Currently, Gafchromic films are considered the gold standard for patient QA. Previous studies have reported discrepancies of 10–30 $$\%$$ between measured and calculated peak and valley doses. This study aimed to evaluate four types of films (EBT-3, EBT-XD, MD-V3, and HD-V2) to determine the most suitable option for MRT QA. To support dosimetric benchmarking, the microDiamond detector was used as the reference for MRT measurements, and the ionization chamber for broad beam reference dosimetry. Discrepancies were observed between calculated and film-measured peak and valley doses, and several hypotheses were proposed to explain these differences. Possible causes include simplifications in dose calculation engines, intrinsic limitations of the films, uncertainties in experimental setups, and variations in readout methods. The study suggests that MD-V3 may be the most suitable film for MRT dosimetry, offering a dynamic range that effectively covers both peak and valley doses.https://doi.org/10.1038/s41598-025-12449-x |
| spellingShingle | Sarvenaz Keshmiri Gaëtan Lemaire Adélie André Florian Thevenet Alexandre Ocadiz Nicolas Rosuel Benjamin Huffschmidt Yacine Bencheikh Mostafa Ghafooryan-Sangchooli Paolo Pellicioli Raphaël Serduc Jean-François Adam Recent advances in film dosimetry for quality assurance in microbeam radiation therapy Scientific Reports |
| title | Recent advances in film dosimetry for quality assurance in microbeam radiation therapy |
| title_full | Recent advances in film dosimetry for quality assurance in microbeam radiation therapy |
| title_fullStr | Recent advances in film dosimetry for quality assurance in microbeam radiation therapy |
| title_full_unstemmed | Recent advances in film dosimetry for quality assurance in microbeam radiation therapy |
| title_short | Recent advances in film dosimetry for quality assurance in microbeam radiation therapy |
| title_sort | recent advances in film dosimetry for quality assurance in microbeam radiation therapy |
| url | https://doi.org/10.1038/s41598-025-12449-x |
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