Clinical performance evaluation of a plasma dual-target methylation test for the detection of primary liver cancer: a multicenter study

Clinical performance evaluation of a plasma dual-target methylation test for the detection of primary liver cancer: a multicenter study

Abstract Background Primary liver cancer (PLC) is a global health concern. The plasma dual-target methylation (PDTM) test, which interrogates the methylation status of GNB4 and Riplet, exhibits a commendable ability to discriminate hepatocellular carcinoma (HCC) from controls. Nevertheless, its perf...

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Bibliographic Details
Main Authors:	Zhigao Xu, Wanping Chen, Hongsheng Wei, Kui Tan, Lianglu Zhang, Lanlan Dong, Wenjin Liang, Xin Zhou, Tao Zhang, Jian Chen, Chuang Peng, Zhongxin Wang, Shaojun Ye, Qifa Ye
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Clinical Epigenetics
Subjects:	Primary liver cancer diagnosis DNA methylation GNB4 Riplet
Online Access:	https://doi.org/10.1186/s13148-025-01920-1
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