SHEP1 alleviates cardiac ischemia reperfusion injury via targeting G3BP1 to regulate macrophage infiltration and inflammation

SHEP1 alleviates cardiac ischemia reperfusion injury via targeting G3BP1 to regulate macrophage infiltration and inflammation

Abstract The macrophage-associated inflammation response plays an important role in myocardial ischemia-reperfusion injury (MIRI). SHEP1(SH2 domain-containing Eph receptor-binding protein 1) has been implicated in adhesion and migration of inflammatory cells. However, the role and molecular mechanis...

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Main Authors: Tingwen Gao, Zhenyang Guo, Xinyu Weng, Yikai Cui, Peng Li, Tao Hu, Wei Luo, Zheng Dong, Peng Wei, Yun Cai, Yijing Lu, Rifeng Gao, Hua Li, Xin Zhong, Junbo Ge
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07282-5
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