Mucormycosis: An Emerging Fungal Infection in the COVID-19 Pandemic
During the COVID-19 pandemic, there has been a resurgence of mucormycosis, a rare and opportunistic fungal infection, with India reporting a particularly notable increase in incidence. Mucormycosis is a life-threatening condition that requires prompt diagnosis and treatment to prevent high morta...
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| Format: | Article |
| Language: | English |
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Pasteur Institute of Iran
2024-06-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
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| Online Access: | https://jommid.pasteur.ac.ir/article-1-558-en.html |
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| author | Parisa Saberi-Hasanabadi1, 2 Milad Esmaeilzadeh Farmad3 Ramin Ataee4 |
| author_facet | Parisa Saberi-Hasanabadi1, 2 Milad Esmaeilzadeh Farmad3 Ramin Ataee4 |
| author_sort | Parisa Saberi-Hasanabadi1, 2 |
| collection | DOAJ |
| description | During the COVID-19 pandemic, there has been a resurgence of
mucormycosis, a rare and opportunistic fungal infection, with India
reporting a particularly notable increase in incidence. Mucormycosis is a
life-threatening condition that requires prompt diagnosis and treatment to
prevent high mortality rates and severe sequelae. It is caused by the
inhalation of spores from ubiquitous filamentous fungi belonging to the
order Mucorales. Individuals with compromised immune systems or
underlying conditions, such as diabetes, ketoacidosis, and neutropenia, are
particularly vulnerable to infection. The risk and severity of mucormycosis
are exacerbated by several factors, including corticosteroid therapy,
prolonged intensive care stay, and the use of ventilators. Additionally,
contaminated oxygen humidifiers pose a significant risk. Effective
management of mucormycosis in critically ill COVID-19 patients relies on
early diagnosis, optimization of predisposing factors, timely antifungal
treatment, surgical debridement, and adjuvant therapies. Imaging modalities
such as contrast-enhanced CT scans and MRI are crucial for guiding surgical
debridement and assessing disease extent. This review article provides a
comprehensive overview of the clinical pathogenesis, risk factors, diagnosis,
treatment, and challenges associated with mucormycosis in COVID-19
patients, summarizing the latest findings in this field. |
| format | Article |
| id | doaj-art-0ae66bbcc7fd4acf9aab1d71e8913486 |
| institution | DOAJ |
| issn | 2345-5349 2345-5330 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Pasteur Institute of Iran |
| record_format | Article |
| series | Journal of Medical Microbiology and Infectious Diseases |
| spelling | doaj-art-0ae66bbcc7fd4acf9aab1d71e89134862025-08-20T03:09:38ZengPasteur Institute of IranJournal of Medical Microbiology and Infectious Diseases2345-53492345-53302024-06-01122849910.61186/JoMMID.12.2.84Mucormycosis: An Emerging Fungal Infection in the COVID-19 PandemicParisa Saberi-Hasanabadi1, 20https://orcid.org/0000-0001-8775-4582Milad Esmaeilzadeh Farmad31https://orcid.org/0009-0004-9225-6157Ramin Ataee42https://orcid.org/0000-0002-6342-03821Ph.D in Toxicology and pharmacology, Faculty of pharmacy, Mazandaran University of Medical Sciences, Sari, Iran; 2Student Research Committee, Mazandaran University of Medical sciences, Sari, Iran39th Dey of Torbat Heydariyeh Hospital, Mashhad University of Medical Sciences, Mashhad, Iran4Medicinal Plants Research Center, Mazandaran University of Medical Sciences, Sari, IranDuring the COVID-19 pandemic, there has been a resurgence of mucormycosis, a rare and opportunistic fungal infection, with India reporting a particularly notable increase in incidence. Mucormycosis is a life-threatening condition that requires prompt diagnosis and treatment to prevent high mortality rates and severe sequelae. It is caused by the inhalation of spores from ubiquitous filamentous fungi belonging to the order Mucorales. Individuals with compromised immune systems or underlying conditions, such as diabetes, ketoacidosis, and neutropenia, are particularly vulnerable to infection. The risk and severity of mucormycosis are exacerbated by several factors, including corticosteroid therapy, prolonged intensive care stay, and the use of ventilators. Additionally, contaminated oxygen humidifiers pose a significant risk. Effective management of mucormycosis in critically ill COVID-19 patients relies on early diagnosis, optimization of predisposing factors, timely antifungal treatment, surgical debridement, and adjuvant therapies. Imaging modalities such as contrast-enhanced CT scans and MRI are crucial for guiding surgical debridement and assessing disease extent. This review article provides a comprehensive overview of the clinical pathogenesis, risk factors, diagnosis, treatment, and challenges associated with mucormycosis in COVID-19 patients, summarizing the latest findings in this field.https://jommid.pasteur.ac.ir/article-1-558-en.htmlcovid-19 infectionsmucormycetesorgan damagerisk factors and linkages |
| spellingShingle | Parisa Saberi-Hasanabadi1, 2 Milad Esmaeilzadeh Farmad3 Ramin Ataee4 Mucormycosis: An Emerging Fungal Infection in the COVID-19 Pandemic Journal of Medical Microbiology and Infectious Diseases covid-19 infections mucormycetes organ damage risk factors and linkages |
| title | Mucormycosis: An Emerging Fungal Infection in the COVID-19 Pandemic |
| title_full | Mucormycosis: An Emerging Fungal Infection in the COVID-19 Pandemic |
| title_fullStr | Mucormycosis: An Emerging Fungal Infection in the COVID-19 Pandemic |
| title_full_unstemmed | Mucormycosis: An Emerging Fungal Infection in the COVID-19 Pandemic |
| title_short | Mucormycosis: An Emerging Fungal Infection in the COVID-19 Pandemic |
| title_sort | mucormycosis an emerging fungal infection in the covid 19 pandemic |
| topic | covid-19 infections mucormycetes organ damage risk factors and linkages |
| url | https://jommid.pasteur.ac.ir/article-1-558-en.html |
| work_keys_str_mv | AT parisasaberihasanabadi12 mucormycosisanemergingfungalinfectioninthecovid19pandemic AT miladesmaeilzadehfarmad3 mucormycosisanemergingfungalinfectioninthecovid19pandemic AT raminataee4 mucormycosisanemergingfungalinfectioninthecovid19pandemic |