Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration
Alterations in the mesenchymal-epithelial transition factor (MET) gene are critical drivers of non-small cell lung cancer (NSCLC). In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients. These alterations include MET...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
China Anti-Cancer Association
2025-03-01
|
| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | https://www.cancerbiomed.org/content/22/3/237 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850186899433455616 |
|---|---|
| author | Huijing Feng Yang Xia Wenxian Wang Chunwei Xu Qian Wang Zhengbo Song Ziming Li Jinpu Yu Wenzhao Zhong Zhijie Wang Yongchang Zhang Jingjing Liu Shirong Zhang Xiuyu Cai Anwen Liu Wen Li Ping Zhan Hongbing Liu Tangfeng Lyu Liyun Miao Lingfeng Min Gen Lin Long Huang Jingping Yuan Zhansheng Jiang Xingxiang Pu Chuangzhou Rao Dongqing Lyu Zongyang Yu Xiaoyan Li Chuanhao Tang Chengzhi Zhou Qi Mei Hui Guo Qian Chu Rui Meng Xuewen Liu Jingxun Wu Jin Zhou Zhengfei Zhu Weiwei Pan Fei Pang Meizhen Hu Kai Wang Fan Wu Bingwei Xu Ling Xu Liping Wang Youcai Zhu Jisheng Li Yanru Xie Xinqing Lin Jing Cai Lin Wang Yingying Du Wang Yao Xuefei Shi Xiaomin Niu Dongmei Yuan Yanwen Yao Jing Kang Jiatao Zhang Chao Zhang Wenbin Gao Jianhui Huang Yinbin Zhang Pingli Sun Hong Wang Mingxiang Ye Dong Wang Zhaofeng Wang Yue Hao Zheng Wang Bing Wan Donglai Lyu Xiaodong Jiao Lin Shi Gang Lan Shengjie Yang Yanhong Shang Yina Wang Bihui Li Gang Jin Kang Zheng Jun Ma Wenfeng Li Zhang Zhang Zhongwu Li Yuan Li Zhefeng Liu Xuelei Ma Nong Yang Lin Wu Qiming Wang Guansong Wang Zhuan Hong Jiandong Wang Meiyu Fang Yong Fang Xixu Zhu Yi Shen Ke Wang Xiubao Ren Yiping Zhang Shenglin Ma Junping Zhang Yong Song Wenfeng Fang Yuanzhi Lu |
| author_facet | Huijing Feng Yang Xia Wenxian Wang Chunwei Xu Qian Wang Zhengbo Song Ziming Li Jinpu Yu Wenzhao Zhong Zhijie Wang Yongchang Zhang Jingjing Liu Shirong Zhang Xiuyu Cai Anwen Liu Wen Li Ping Zhan Hongbing Liu Tangfeng Lyu Liyun Miao Lingfeng Min Gen Lin Long Huang Jingping Yuan Zhansheng Jiang Xingxiang Pu Chuangzhou Rao Dongqing Lyu Zongyang Yu Xiaoyan Li Chuanhao Tang Chengzhi Zhou Qi Mei Hui Guo Qian Chu Rui Meng Xuewen Liu Jingxun Wu Jin Zhou Zhengfei Zhu Weiwei Pan Fei Pang Meizhen Hu Kai Wang Fan Wu Bingwei Xu Ling Xu Liping Wang Youcai Zhu Jisheng Li Yanru Xie Xinqing Lin Jing Cai Lin Wang Yingying Du Wang Yao Xuefei Shi Xiaomin Niu Dongmei Yuan Yanwen Yao Jing Kang Jiatao Zhang Chao Zhang Wenbin Gao Jianhui Huang Yinbin Zhang Pingli Sun Hong Wang Mingxiang Ye Dong Wang Zhaofeng Wang Yue Hao Zheng Wang Bing Wan Donglai Lyu Xiaodong Jiao Lin Shi Gang Lan Shengjie Yang Yanhong Shang Yina Wang Bihui Li Gang Jin Kang Zheng Jun Ma Wenfeng Li Zhang Zhang Zhongwu Li Yuan Li Zhefeng Liu Xuelei Ma Nong Yang Lin Wu Qiming Wang Guansong Wang Zhuan Hong Jiandong Wang Meiyu Fang Yong Fang Xixu Zhu Yi Shen Ke Wang Xiubao Ren Yiping Zhang Shenglin Ma Junping Zhang Yong Song Wenfeng Fang Yuanzhi Lu |
| author_sort | Huijing Feng |
| collection | DOAJ |
| description | Alterations in the mesenchymal-epithelial transition factor (MET) gene are critical drivers of non-small cell lung cancer (NSCLC). In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients. These alterations include MET exon 14 skipping mutations (MET exon 14 skipping), MET gene amplifications, MET point mutations (primarily kinase domain mutations), and MET protein overexpression. Accurate identification of these alterations and appropriate selection of patient populations and targeted therapies are essential for improving clinical outcomes. The East China Lung Cancer Group, Youth Committee (ECLUNG YOUNG, Yangtze River Delta Lung Cancer Cooperation Group) has synthesized insights from China’s innovative drug development landscape and clinical practice to formulate an expert consensus on the diagnosis and treatment of NSCLC patients with MET alterations. This consensus addresses key areas, such as optimal testing timing, testing methods, testing strategies, quality control measures, and treatment approaches. By offering standardized recommendations, this guidance aims to streamline diagnostic and therapeutic processes and enhance clinical decision-making for NSCLC with MET alterations. |
| format | Article |
| id | doaj-art-0ae31f5eeaed4fe28f1f76aa9875953b |
| institution | OA Journals |
| issn | 2095-3941 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj-art-0ae31f5eeaed4fe28f1f76aa9875953b2025-08-20T02:16:14ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412025-03-0122323726510.20892/j.issn.2095-3941.2024.0503Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alterationHuijing Feng0Yang Xia1Wenxian Wang2Chunwei Xu3Qian Wang4Zhengbo Song5Ziming Li6Jinpu Yu7Wenzhao Zhong8Zhijie Wang9Yongchang Zhang10Jingjing Liu11Shirong Zhang12Xiuyu Cai13Anwen Liu14Wen Li15Ping Zhan16Hongbing Liu17Tangfeng Lyu18Liyun Miao19Lingfeng Min20Gen Lin21Long Huang22Jingping Yuan23Zhansheng Jiang24Xingxiang Pu25Chuangzhou Rao26Dongqing Lyu27Zongyang Yu28Xiaoyan Li29Chuanhao Tang30Chengzhi Zhou31Qi Mei32Hui Guo33Qian Chu34Rui Meng35Xuewen Liu36Jingxun Wu37Jin Zhou38Zhengfei Zhu39Weiwei Pan40Fei Pang41Meizhen Hu42Kai Wang43Fan Wu44Bingwei Xu45Ling Xu46Liping Wang47Youcai Zhu48Jisheng Li49Yanru Xie50Xinqing Lin51Jing Cai52Lin Wang53Yingying Du54Wang Yao55Xuefei Shi56Xiaomin Niu57Dongmei Yuan58Yanwen Yao59Jing Kang60Jiatao Zhang61Chao Zhang62Wenbin Gao63Jianhui Huang64Yinbin Zhang65Pingli Sun66Hong Wang67Mingxiang Ye68Dong Wang69Zhaofeng Wang70Yue Hao71Zheng Wang72Bing Wan73Donglai Lyu74Xiaodong Jiao75Lin Shi76Gang Lan77Shengjie Yang78Yanhong Shang79Yina Wang80Bihui Li81Gang Jin82Kang Zheng83Jun Ma84Wenfeng Li85Zhang Zhang86Zhongwu Li87Yuan Li88Zhefeng Liu89Xuelei Ma90Nong Yang91Lin Wu92Qiming Wang93Guansong Wang94Zhuan Hong95Jiandong Wang96Meiyu Fang97Yong Fang98Xixu Zhu99Yi Shen100Ke Wang101Xiubao Ren102Yiping Zhang103Shenglin Ma104Junping Zhang105Yong Song106Wenfeng Fang107Yuanzhi Lu108Department of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032, ChinaKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou 310009, ChinaDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, ChinaInstitute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou 310022, ChinaDepartment of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, ChinaDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, ChinaDepartment of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, ChinaDepartment of Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, ChinaGuangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou 510080, ChinaState Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, ChinaDepartment of Thoracic Cancer, Jilin Cancer Hospital, Changchun 130012, ChinaTranslational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou 310006, ChinaDepartment of VIP Inpatient, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, ChinaDepartment of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaKey Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou 310009, ChinaDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Respiratory Medicine, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, ChinaDepartment of Respiratory Medicine, Clinical Medical School of Yangzhou University, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, ChinaDepartment of Medical Oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Integrative Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, ChinaDepartment of Medical Oncology, Lung Cancer and Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, ChinaDepartment of Radiotherapy and Chemotherapy, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, ChinaDepartment of Pulmonary Medicine, Taizhou Hospital of Wenzhou Medical University, Taizhou 317000, ChinaDepartment of Respiratory Medicine, the 900th Hospital of the Joint Logistics Team (the Former Fuzhou General Hospital), Fujian Medical University, Fuzhou 350025, ChinaDepartment of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100700, ChinaDepartment of Medical Oncology, Peking University International Hospital, Beijing 102206, ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease; Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510300, ChinaDepartment of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Oncology, the Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Medical Oncology, the First Affiliated Hospital of Medicine, Xiamen University, Xiamen 361003, ChinaDepartment of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, ChinaDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaDepartment of Cell Biology, College of Medicine, Jiaxing University, Jiaxing 314001, ChinaShanghai OrigiMed Co, Ltd, Shanghai 201114, ChinaShanghai OrigiMed Co, Ltd, Shanghai 201114, ChinaShanghai OrigiMed Co, Ltd, Shanghai 201114, ChinaMenarini Silicon Biosystems SpA, Shanghai 200333, ChinaDepartment of Biotherapy, Cancer Institute, First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Interventional Pulmonary Diseases, Anhui Chest Hospital, Hefei 230011, ChinaDepartment of Oncology, Baotou Cancer Hospital, Baotou 014000, ChinaDepartment of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing 314000, ChinaDepartment of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, ChinaDepartment of Oncology, Lishui Municipal Central Hospital, Lishui 323000, ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease; Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510300, ChinaDepartment of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaDepartment of Pathology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032, ChinaDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510060, ChinaDepartment of Respiratory Medicine, Huzhou Hospital, Zhejiang University School of Medicine, Huzhou 313000, ChinaDepartment of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, ChinaDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaGuangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou 510080, ChinaGuangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou 510080, ChinaGuangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou 510080, ChinaDepartment of Oncology, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518001, ChinaDepartment of Oncology, Lishui Municipal Central Hospital, Lishui 323000, ChinaDepartment of Oncology, the Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, ChinaDepartment of Pathology, The Second Hospital of Jilin University, Changchun 130041, ChinaSenior Department of Oncology, The 5th Medical Center of Chinese PLA General Hospital, Beijing 100071, ChinaDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, ChinaDepartment of Radiation Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Respiratory Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 210002, ChinaDepartment of Clinical Oncology, The 901 Hospital of Joint Logistics Support Force of People Liberation Army, Hefei 230031, ChinaDepartment of Medical Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200070, ChinaDepartment of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing 314000, ChinaDepartment of Thoracic Surgery, Chuxiong Yi Autonomous Prefecture People’s Hospital, Chuxiong 675000, ChinaDepartment of Medical Oncology, Affiliated Hospital of Hebei University, Baoding 071000, ChinaDepartment of Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, ChinaDepartment of Oncology, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, ChinaDepartment of Oncology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, ChinaDepartment of Thoracic Surgery, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, ChinaDepartment of Thoracic Surgery, Shanxi Provincial People’s Hospital/The Fifth Hospital of Shanxi Medical University/The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan 030012, ChinaDepartment of Radiation Oncology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, ChinaInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou 510632, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing 100142, ChinaDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, ChinaSenior Department of Oncology, The 5th Medical Center of Chinese PLA General Hospital, Beijing 100071, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, ChinaDepartment of Medical Oncology, Lung Cancer and Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, ChinaDepartment of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Medical Oncology, Jiangsu Cancer Hospital, Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210029, ChinaDepartment of Pathology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, ChinaDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, ChinaDepartment of Radiation Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Thoracic Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaNational Health Commission (NHC) Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, ChinaDepartment of Immunology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, ChinaDepartment of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, ChinaDepartment of Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou Cancer Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou 310006, ChinaDepartment of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032, ChinaDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, ChinaDepartment of Clinical Pathology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaAlterations in the mesenchymal-epithelial transition factor (MET) gene are critical drivers of non-small cell lung cancer (NSCLC). In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients. These alterations include MET exon 14 skipping mutations (MET exon 14 skipping), MET gene amplifications, MET point mutations (primarily kinase domain mutations), and MET protein overexpression. Accurate identification of these alterations and appropriate selection of patient populations and targeted therapies are essential for improving clinical outcomes. The East China Lung Cancer Group, Youth Committee (ECLUNG YOUNG, Yangtze River Delta Lung Cancer Cooperation Group) has synthesized insights from China’s innovative drug development landscape and clinical practice to formulate an expert consensus on the diagnosis and treatment of NSCLC patients with MET alterations. This consensus addresses key areas, such as optimal testing timing, testing methods, testing strategies, quality control measures, and treatment approaches. By offering standardized recommendations, this guidance aims to streamline diagnostic and therapeutic processes and enhance clinical decision-making for NSCLC with MET alterations.https://www.cancerbiomed.org/content/22/3/237mesenchymal-epithelial transition factormet exon 14 skipping mutationmet amplificationnon-small cell lung cancerprecision medicinetargeted therapytyrosine kinase |
| spellingShingle | Huijing Feng Yang Xia Wenxian Wang Chunwei Xu Qian Wang Zhengbo Song Ziming Li Jinpu Yu Wenzhao Zhong Zhijie Wang Yongchang Zhang Jingjing Liu Shirong Zhang Xiuyu Cai Anwen Liu Wen Li Ping Zhan Hongbing Liu Tangfeng Lyu Liyun Miao Lingfeng Min Gen Lin Long Huang Jingping Yuan Zhansheng Jiang Xingxiang Pu Chuangzhou Rao Dongqing Lyu Zongyang Yu Xiaoyan Li Chuanhao Tang Chengzhi Zhou Qi Mei Hui Guo Qian Chu Rui Meng Xuewen Liu Jingxun Wu Jin Zhou Zhengfei Zhu Weiwei Pan Fei Pang Meizhen Hu Kai Wang Fan Wu Bingwei Xu Ling Xu Liping Wang Youcai Zhu Jisheng Li Yanru Xie Xinqing Lin Jing Cai Lin Wang Yingying Du Wang Yao Xuefei Shi Xiaomin Niu Dongmei Yuan Yanwen Yao Jing Kang Jiatao Zhang Chao Zhang Wenbin Gao Jianhui Huang Yinbin Zhang Pingli Sun Hong Wang Mingxiang Ye Dong Wang Zhaofeng Wang Yue Hao Zheng Wang Bing Wan Donglai Lyu Xiaodong Jiao Lin Shi Gang Lan Shengjie Yang Yanhong Shang Yina Wang Bihui Li Gang Jin Kang Zheng Jun Ma Wenfeng Li Zhang Zhang Zhongwu Li Yuan Li Zhefeng Liu Xuelei Ma Nong Yang Lin Wu Qiming Wang Guansong Wang Zhuan Hong Jiandong Wang Meiyu Fang Yong Fang Xixu Zhu Yi Shen Ke Wang Xiubao Ren Yiping Zhang Shenglin Ma Junping Zhang Yong Song Wenfeng Fang Yuanzhi Lu Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration Cancer Biology & Medicine mesenchymal-epithelial transition factor met exon 14 skipping mutation met amplification non-small cell lung cancer precision medicine targeted therapy tyrosine kinase |
| title | Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration |
| title_full | Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration |
| title_fullStr | Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration |
| title_full_unstemmed | Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration |
| title_short | Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration |
| title_sort | expert consensus on the diagnosis and treatment of non small cell lung cancer with met alteration |
| topic | mesenchymal-epithelial transition factor met exon 14 skipping mutation met amplification non-small cell lung cancer precision medicine targeted therapy tyrosine kinase |
| url | https://www.cancerbiomed.org/content/22/3/237 |
| work_keys_str_mv | AT huijingfeng expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yangxia expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT wenxianwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT chunweixu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT qianwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhengbosong expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zimingli expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jinpuyu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT wenzhaozhong expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhijiewang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yongchangzhang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jingjingliu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT shirongzhang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xiuyucai expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT anwenliu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT wenli expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT pingzhan expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT hongbingliu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT tangfenglyu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT liyunmiao expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT lingfengmin expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT genlin expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT longhuang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jingpingyuan expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhanshengjiang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xingxiangpu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT chuangzhourao expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT dongqinglyu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zongyangyu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xiaoyanli expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT chuanhaotang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT chengzhizhou expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT qimei expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT huiguo expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT qianchu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT ruimeng expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xuewenliu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jingxunwu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jinzhou expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhengfeizhu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT weiweipan expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT feipang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT meizhenhu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT kaiwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT fanwu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT bingweixu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT lingxu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT lipingwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT youcaizhu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jishengli expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yanruxie expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xinqinglin expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jingcai expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT linwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yingyingdu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT wangyao expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xuefeishi expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xiaominniu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT dongmeiyuan expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yanwenyao expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jingkang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jiataozhang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT chaozhang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT wenbingao expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jianhuihuang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yinbinzhang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT pinglisun expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT hongwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT mingxiangye expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT dongwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhaofengwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yuehao expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhengwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT bingwan expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT donglailyu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xiaodongjiao expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT linshi expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT ganglan expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT shengjieyang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yanhongshang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yinawang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT bihuili expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT gangjin expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT kangzheng expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT junma expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT wenfengli expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhangzhang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhongwuli expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yuanli expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhefengliu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xueleima expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT nongyang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT linwu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT qimingwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT guansongwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT zhuanhong expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT jiandongwang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT meiyufang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yongfang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xixuzhu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yishen expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT kewang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT xiubaoren expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yipingzhang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT shenglinma expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT junpingzhang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yongsong expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT wenfengfang expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration AT yuanzhilu expertconsensusonthediagnosisandtreatmentofnonsmallcelllungcancerwithmetalteration |