Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts
Background Globally, adult Indigenous people, including Aboriginal Australians, have a high burden of chronic respiratory disorders, and bronchiectasis is no exception. However, literature detailing bronchiectasis disease characteristics among adult Indigenous people is sparse. This study assessed t...
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/12/1/e002139.full |
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| author | Timothy Howarth Subash Heraganahally Claire Gibbs Lata Jayaram Asanga Abeyaratne Shiidheshwar J Ravichandran Davaadorj Erdenebayar Winnie Chen Hubertus Jersmann |
| author_facet | Timothy Howarth Subash Heraganahally Claire Gibbs Lata Jayaram Asanga Abeyaratne Shiidheshwar J Ravichandran Davaadorj Erdenebayar Winnie Chen Hubertus Jersmann |
| author_sort | Timothy Howarth |
| collection | DOAJ |
| description | Background Globally, adult Indigenous people, including Aboriginal Australians, have a high burden of chronic respiratory disorders, and bronchiectasis is no exception. However, literature detailing bronchiectasis disease characteristics among adult Indigenous people is sparse. This study assessed the clinical profile of bronchiectasis among adult Aboriginal Australians and compared against previously published international bronchiectasis registry reports.Methods Aboriginal Australians aged >18 years with chest CT confirmed bronchiectasis between 2011 and 2020 in the Top End Northern Territory of Australia were included. Demographics, chest CT findings, pulmonary function results, sputum microbiology, coexistent medical comorbidities, and pharmacotherapy use were assessed and compared against five published international bronchiectasis registry reports (Australian (ABR), European (European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC)-Europe), Indian (EMBARC-India), Korean (KMBARC) and the USA (USBRR)).Results A total of 459 patients were assessed. In comparison with international and non-Aboriginal Australian national cohorts, Aboriginal Australians were younger (median 56 years (IQR (48, 65)); however, sex distribution (55% female) and body mass index (23 kg/m2 (IQR 19.4–27)) were comparable . Smoking rates were higher at 85% compared with other registry cohorts (22–46%) as was the prevalence of comorbidities (97%): cardiovascular diseases (73%), diabetes mellitus (50%) and chronic obstructive pulmonary disease (83%) compared with other registry cohorts (4–32%; 6–14%; and 14–37%, respectively). Spirometry demonstrated forced expiratory volume in 1 s of 38% predicted in comparison with 61–77% in other cohorts. Sputum microbiology showed Haemophilus influenzae (57%) isolated at 3.4 to 6 times the rate of other registry cohorts and Pseudomonas aeruginosa in 31%. Chest CT demonstrated multilobar and lower lobes involvement in 73% and inhaled pharmacotherapy use was recorded in up to 62% and long-term antibiotics in 5%.Conclusion The overall bronchiectasis disease burden is higher in Aboriginal Australian adults in comparison with global ethnically diverse non-Indigenous populations. Further efforts are required to address this disparity secondary to bronchiectasis among Indigenous people. |
| format | Article |
| id | doaj-art-0ae05ce5bf394634af3f1072a8b95dcb |
| institution | Kabale University |
| issn | 2052-4439 |
| language | English |
| publishDate | 2025-01-01 |
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| series | BMJ Open Respiratory Research |
| spelling | doaj-art-0ae05ce5bf394634af3f1072a8b95dcb2025-01-23T11:00:09ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392025-01-0112110.1136/bmjresp-2023-002139Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohortsTimothy Howarth0Subash Heraganahally1Claire Gibbs2Lata Jayaram3Asanga Abeyaratne4Shiidheshwar J Ravichandran5Davaadorj Erdenebayar6Winnie Chen7Hubertus Jersmann8Department of Technical Physics, University of Eastern Finland - Kuopio Campus, Kuopio, Pohjois-Savo, FinlandDepartment of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, AustraliaDepartment of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, AustraliaDepartment of Respiratory and Sleep, Western Health, Footscray, Victoria, AustraliaDivision of General Medicine, Royal Darwin Hospital, Darwin, Northern Territory, AustraliaDivision of General Medicine, Royal Darwin Hospital, Darwin, Northern Territory, AustraliaDivision of General Medicine, Royal Darwin Hospital, Darwin, Northern Territory, AustraliaNorthern Territory Medical Program, Flinders University College of Medicine and Public Health, Darwin, Northern Territory, AustraliaDepartment of Respiratory and Sleep, Royal Adelaide Hospital, Adelaide, South Australia, AustraliaBackground Globally, adult Indigenous people, including Aboriginal Australians, have a high burden of chronic respiratory disorders, and bronchiectasis is no exception. However, literature detailing bronchiectasis disease characteristics among adult Indigenous people is sparse. This study assessed the clinical profile of bronchiectasis among adult Aboriginal Australians and compared against previously published international bronchiectasis registry reports.Methods Aboriginal Australians aged >18 years with chest CT confirmed bronchiectasis between 2011 and 2020 in the Top End Northern Territory of Australia were included. Demographics, chest CT findings, pulmonary function results, sputum microbiology, coexistent medical comorbidities, and pharmacotherapy use were assessed and compared against five published international bronchiectasis registry reports (Australian (ABR), European (European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC)-Europe), Indian (EMBARC-India), Korean (KMBARC) and the USA (USBRR)).Results A total of 459 patients were assessed. In comparison with international and non-Aboriginal Australian national cohorts, Aboriginal Australians were younger (median 56 years (IQR (48, 65)); however, sex distribution (55% female) and body mass index (23 kg/m2 (IQR 19.4–27)) were comparable . Smoking rates were higher at 85% compared with other registry cohorts (22–46%) as was the prevalence of comorbidities (97%): cardiovascular diseases (73%), diabetes mellitus (50%) and chronic obstructive pulmonary disease (83%) compared with other registry cohorts (4–32%; 6–14%; and 14–37%, respectively). Spirometry demonstrated forced expiratory volume in 1 s of 38% predicted in comparison with 61–77% in other cohorts. Sputum microbiology showed Haemophilus influenzae (57%) isolated at 3.4 to 6 times the rate of other registry cohorts and Pseudomonas aeruginosa in 31%. Chest CT demonstrated multilobar and lower lobes involvement in 73% and inhaled pharmacotherapy use was recorded in up to 62% and long-term antibiotics in 5%.Conclusion The overall bronchiectasis disease burden is higher in Aboriginal Australian adults in comparison with global ethnically diverse non-Indigenous populations. Further efforts are required to address this disparity secondary to bronchiectasis among Indigenous people.https://bmjopenrespres.bmj.com/content/12/1/e002139.full |
| spellingShingle | Timothy Howarth Subash Heraganahally Claire Gibbs Lata Jayaram Asanga Abeyaratne Shiidheshwar J Ravichandran Davaadorj Erdenebayar Winnie Chen Hubertus Jersmann Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts BMJ Open Respiratory Research |
| title | Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts |
| title_full | Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts |
| title_fullStr | Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts |
| title_full_unstemmed | Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts |
| title_short | Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts |
| title_sort | retrospective cross sectional study on bronchiectasis in adult aboriginal australians disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts |
| url | https://bmjopenrespres.bmj.com/content/12/1/e002139.full |
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