Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens
Rabdosia rubescens, a Chinese herbal medicine with anticancer properties, contains two active ingredients: oridonin and ponicidin. Both compounds exhibit antitumor effects by inducing tumor cell apoptosis and autophagy and inhibiting tumor cell proliferation. To further explore the differences in mo...
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2024.1460123/full |
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| author | Yang Gao Yang Gao Yang Gao Yang Gao Zhuang Peng Zhuang Peng Zhuang Peng Zhuang Peng Huiyu Yang Huiyu Yang Huiyu Yang Huiyu Yang Xinrui Zhang Xinrui Zhang Xinrui Zhang Xinrui Zhang Yuhan Zhao Yuhan Zhao Yuhan Zhao Yuhan Zhao Zeyu Hou Zeyu Hou Zeyu Hou Zeyu Hou Bo Su Bo Su Bo Su Bo Su Kai Li Kai Li Kai Li Cunlin Zhang Cunlin Zhang Cunlin Zhang |
| author_facet | Yang Gao Yang Gao Yang Gao Yang Gao Zhuang Peng Zhuang Peng Zhuang Peng Zhuang Peng Huiyu Yang Huiyu Yang Huiyu Yang Huiyu Yang Xinrui Zhang Xinrui Zhang Xinrui Zhang Xinrui Zhang Yuhan Zhao Yuhan Zhao Yuhan Zhao Yuhan Zhao Zeyu Hou Zeyu Hou Zeyu Hou Zeyu Hou Bo Su Bo Su Bo Su Bo Su Kai Li Kai Li Kai Li Cunlin Zhang Cunlin Zhang Cunlin Zhang |
| author_sort | Yang Gao |
| collection | DOAJ |
| description | Rabdosia rubescens, a Chinese herbal medicine with anticancer properties, contains two active ingredients: oridonin and ponicidin. Both compounds exhibit antitumor effects by inducing tumor cell apoptosis and autophagy and inhibiting tumor cell proliferation. To further explore the differences in molecular structure and pharmacological properties between the two substances, this study employs Terahertz Time-Domain Spectroscopy (THz-TDS) to investigate the spectral characteristics of oridonin and ponicidin in the frequency range of 0.1 to 2.3 THz. The crystal structures of the two substances are simulated using Materials Studio software and Density Functional Theory (DFT), yielding their spectra and molecular vibration modes, which elucidate the mechanism underlying the peak generation. The consistency between experimental and simulation results confirms the reliability of the experimental findings. Thus, THz spectroscopy can effectively distinguish between these two substances. Finally, a THz detection is performed on Rabdosia rubescens capsules purchased from the market, revealing the presence of absorption peaks for both substances in their absorption spectra. This provides a new approach for detecting active ingredients in Chinese herbal medicines. |
| format | Article |
| id | doaj-art-0ad8aab5b3e44b75b8a8134f4ea98435 |
| institution | OA Journals |
| issn | 1664-462X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj-art-0ad8aab5b3e44b75b8a8134f4ea984352025-08-20T02:12:10ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2024-10-011510.3389/fpls.2024.14601231460123Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescensYang Gao0Yang Gao1Yang Gao2Yang Gao3Zhuang Peng4Zhuang Peng5Zhuang Peng6Zhuang Peng7Huiyu Yang8Huiyu Yang9Huiyu Yang10Huiyu Yang11Xinrui Zhang12Xinrui Zhang13Xinrui Zhang14Xinrui Zhang15Yuhan Zhao16Yuhan Zhao17Yuhan Zhao18Yuhan Zhao19Zeyu Hou20Zeyu Hou21Zeyu Hou22Zeyu Hou23Bo Su24Bo Su25Bo Su26Bo Su27Kai Li28Kai Li29Kai Li30Cunlin Zhang31Cunlin Zhang32Cunlin Zhang33Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, ChinaBeijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, ChinaBeijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, ChinaDepartment of Physics, Capital Normal University, Beijing, ChinaKey Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, ChinaBeijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, ChinaBeijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, ChinaDepartment of Physics, Capital Normal University, Beijing, ChinaKey Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, ChinaBeijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, ChinaBeijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, ChinaDepartment of Physics, Capital Normal University, Beijing, ChinaKey Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, ChinaBeijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, ChinaBeijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, ChinaDepartment of Physics, Capital Normal University, Beijing, ChinaKey Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, ChinaBeijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, ChinaBeijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, ChinaDepartment of Physics, Capital Normal University, Beijing, ChinaKey Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, ChinaBeijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, ChinaBeijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, ChinaDepartment of Physics, Capital Normal University, Beijing, ChinaKey Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, ChinaBeijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, ChinaBeijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, ChinaDepartment of Physics, Capital Normal University, Beijing, ChinaBeijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, ChinaBeijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, ChinaDepartment of Physics, Capital Normal University, Beijing, ChinaKey Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, ChinaBeijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, ChinaBeijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, ChinaRabdosia rubescens, a Chinese herbal medicine with anticancer properties, contains two active ingredients: oridonin and ponicidin. Both compounds exhibit antitumor effects by inducing tumor cell apoptosis and autophagy and inhibiting tumor cell proliferation. To further explore the differences in molecular structure and pharmacological properties between the two substances, this study employs Terahertz Time-Domain Spectroscopy (THz-TDS) to investigate the spectral characteristics of oridonin and ponicidin in the frequency range of 0.1 to 2.3 THz. The crystal structures of the two substances are simulated using Materials Studio software and Density Functional Theory (DFT), yielding their spectra and molecular vibration modes, which elucidate the mechanism underlying the peak generation. The consistency between experimental and simulation results confirms the reliability of the experimental findings. Thus, THz spectroscopy can effectively distinguish between these two substances. Finally, a THz detection is performed on Rabdosia rubescens capsules purchased from the market, revealing the presence of absorption peaks for both substances in their absorption spectra. This provides a new approach for detecting active ingredients in Chinese herbal medicines.https://www.frontiersin.org/articles/10.3389/fpls.2024.1460123/fullterahertzoridoninponicidinRaman spectroscopyPXRD |
| spellingShingle | Yang Gao Yang Gao Yang Gao Yang Gao Zhuang Peng Zhuang Peng Zhuang Peng Zhuang Peng Huiyu Yang Huiyu Yang Huiyu Yang Huiyu Yang Xinrui Zhang Xinrui Zhang Xinrui Zhang Xinrui Zhang Yuhan Zhao Yuhan Zhao Yuhan Zhao Yuhan Zhao Zeyu Hou Zeyu Hou Zeyu Hou Zeyu Hou Bo Su Bo Su Bo Su Bo Su Kai Li Kai Li Kai Li Cunlin Zhang Cunlin Zhang Cunlin Zhang Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens Frontiers in Plant Science terahertz oridonin ponicidin Raman spectroscopy PXRD |
| title | Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens |
| title_full | Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens |
| title_fullStr | Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens |
| title_full_unstemmed | Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens |
| title_short | Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens |
| title_sort | terahertz spectroscopy study of oridonin and ponicidin in the anticancer chinese herbal medicine rabdosia rubescens |
| topic | terahertz oridonin ponicidin Raman spectroscopy PXRD |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2024.1460123/full |
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