Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition
This article describes the designing of matrix tablets composed of polyethylene oxides (PEOs) with relative molecular masses of 1 × 106, 2 × 106, and 4 × 106. Percolation thresholds were determined for all of the selected PEO formulations (18, 16, and 12 %, m/m), taking into consideration excipients...
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| Format: | Article |
| Language: | English |
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Sciendo
2021-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2021-0018 |
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| author | Draksler Petra Mikac Urša Laggner Peter Paudel Amrit Janković Biljana |
| author_facet | Draksler Petra Mikac Urša Laggner Peter Paudel Amrit Janković Biljana |
| author_sort | Draksler Petra |
| collection | DOAJ |
| description | This article describes the designing of matrix tablets composed of polyethylene oxides (PEOs) with relative molecular masses of 1 × 106, 2 × 106, and 4 × 106. Percolation thresholds were determined for all of the selected PEO formulations (18, 16, and 12 %, m/m), taking into consideration excipients and tablet surface area which significantly increased the percolation threshold. Moreover, the robustness of the gel layer in PEO matrix tablets was evaluated by magnetic resonance imaging under various mechanical stresses (no flow, 12 mL min−1, and 64 mL−1 of medium flow). Correlations between the percolation threshold and gel thickness (R2 = 0.86), gel thickness and the erosion coefficient (R2 = 0.96) was detected. Furthermore, small-angle X-ray scattering of the selected PEOs detected differences in polymer molecular complexity at the nanoscale. Finally, the ratio of the heat of coalescence to the heat of fusion has confirmed the PEO molecular mass-dependent percolation threshold. |
| format | Article |
| id | doaj-art-0ad7f88e283c459dbef9202f9ed17865 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-0ad7f88e283c459dbef9202f9ed178652025-02-02T11:33:19ZengSciendoActa Pharmaceutica1846-95582021-06-0171221524310.2478/acph-2021-0018acph-2021-0018Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet compositionDraksler Petra0Mikac Urša1Laggner Peter2Paudel Amrit3Janković Biljana4Department of Pharmaceutical Technology Faculty of Pharmacy, University of Ljubljana, 1000Ljubljana, SloveniaJožef Štefan Institute, 1000LjubljanaSloveniaResearch Center for Pharmaceutical Engineering (RCPE)GmbH, 8010, GrazAustriaResearch Center for Pharmaceutical Engineering (RCPE)GmbH, 8010, GrazAustriaDepartment of Pharmaceutical Technology Faculty of Pharmacy, University of Ljubljana, 1000Ljubljana, SloveniaThis article describes the designing of matrix tablets composed of polyethylene oxides (PEOs) with relative molecular masses of 1 × 106, 2 × 106, and 4 × 106. Percolation thresholds were determined for all of the selected PEO formulations (18, 16, and 12 %, m/m), taking into consideration excipients and tablet surface area which significantly increased the percolation threshold. Moreover, the robustness of the gel layer in PEO matrix tablets was evaluated by magnetic resonance imaging under various mechanical stresses (no flow, 12 mL min−1, and 64 mL−1 of medium flow). Correlations between the percolation threshold and gel thickness (R2 = 0.86), gel thickness and the erosion coefficient (R2 = 0.96) was detected. Furthermore, small-angle X-ray scattering of the selected PEOs detected differences in polymer molecular complexity at the nanoscale. Finally, the ratio of the heat of coalescence to the heat of fusion has confirmed the PEO molecular mass-dependent percolation threshold.https://doi.org/10.2478/acph-2021-0018polyethylene oxidemripercolation thresholdsaxswaxs |
| spellingShingle | Draksler Petra Mikac Urša Laggner Peter Paudel Amrit Janković Biljana Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition Acta Pharmaceutica polyethylene oxide mri percolation threshold saxs waxs |
| title | Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition |
| title_full | Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition |
| title_fullStr | Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition |
| title_full_unstemmed | Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition |
| title_short | Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition |
| title_sort | polyethylene oxide matrix tablet swelling evolution the impact of molecular mass and tablet composition |
| topic | polyethylene oxide mri percolation threshold saxs waxs |
| url | https://doi.org/10.2478/acph-2021-0018 |
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