CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer

Abstract Radiotherapy (RT)-elicited antitumor immunity serves as a pivotal mechanism in RT-mediated tumor control. The strategic integration of RT with immunotherapies, particularly immune checkpoint blockade (ICB), is revolutionizing cancer therapeutics, demonstrating remarkable clinical potential....

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Bibliographic Details
Main Authors: Zhengkun Cai, Zeyuan Cheng, Lu Zhang, Yuhan Zhang, Jinming Shi, Jing Jin, Zeyun Mi, Zhiyong Yuan, Zhiqiang Wu
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07964-8
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