CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer
Abstract Radiotherapy (RT)-elicited antitumor immunity serves as a pivotal mechanism in RT-mediated tumor control. The strategic integration of RT with immunotherapies, particularly immune checkpoint blockade (ICB), is revolutionizing cancer therapeutics, demonstrating remarkable clinical potential....
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| Main Authors: | Zhengkun Cai, Zeyuan Cheng, Lu Zhang, Yuhan Zhang, Jinming Shi, Jing Jin, Zeyun Mi, Zhiyong Yuan, Zhiqiang Wu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-08-01
|
| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07964-8 |
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