Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study

Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study

Abstract Previous studies have found that major depressive disorder (MDD) may accelerate overall structural brain aging. Nevertheless, it still remains unknown whether anhedonia, a critical negative prognostic indicator in MDD, further leads to advanced brain aging in specific regions. A total of 31...

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Bibliographic Details
Main Authors: Qingli Mu, Kejing Zhang, Yue Chen, Yuwei Xu, Shaohua Hu, Manli Huang, Peng Zhang, Dong Cui, Shaojia Lu
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03555-5
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