Optical Method for Cardiovascular Risk Marker Uric Acid Removal Assessment during Dialysis
The aim of this study was to estimate the concentration of uric acid (UA) optically by using the original and processed ultraviolet (UV) absorbance spectra of spent dialysate. Also, the effect of using several wavelengths (multi-wavelength algorithms) for estimation was examined. This paper gives an...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/506486 |
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| author | Jana Holmar Ivo Fridolin Fredrik Uhlin Kai Lauri Merike Luman |
| author_facet | Jana Holmar Ivo Fridolin Fredrik Uhlin Kai Lauri Merike Luman |
| author_sort | Jana Holmar |
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| description | The aim of this study was to estimate the concentration of uric acid (UA) optically by using the original and processed ultraviolet (UV) absorbance spectra of spent dialysate. Also, the effect of using several wavelengths (multi-wavelength algorithms) for estimation was examined. This paper gives an overview of seven studies carried out in Linköping, Sweden, and Tallinn, Estonia. A total of 60 patients were monitored over their 188 dialysis treatment procedures. Dialysate samples were taken and analysed by means of UA concentration in a chemical laboratory and with a double-beam spectrophotometer. The measured UV absorbance spectra were processed. Three models for the original and three for the first derivate of UV absorbance were created; concentrations of UA from the different methods were finally compared in terms of mean values and SD. The mean concentration (micromol/L) of UA was 49.7±23.0 measured in the chemical laboratory, and 48.9±22.4 calculated with the best estimate among all models. The concentrations were not significantly different (P≥0.17). It was found that using a multi-wavelength and processed signal approach leads to more accurate results, and therefore these approaches should be used in future. |
| format | Article |
| id | doaj-art-0ad16c752e4d40fd9eff46ecb27b4e95 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0ad16c752e4d40fd9eff46ecb27b4e952025-08-20T02:03:09ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/506486506486Optical Method for Cardiovascular Risk Marker Uric Acid Removal Assessment during DialysisJana Holmar0Ivo Fridolin1Fredrik Uhlin2Kai Lauri3Merike Luman4Department of Biomedical Engineering, Technomedicum, Tallinn University of Technology, Ehitajate tee 5, EST-19086 Tallinn, EstoniaDepartment of Biomedical Engineering, Technomedicum, Tallinn University of Technology, Ehitajate tee 5, EST-19086 Tallinn, EstoniaDepartment of Biomedical Engineering, Technomedicum, Tallinn University of Technology, Ehitajate tee 5, EST-19086 Tallinn, EstoniaDepartment of Biomedical Engineering, Technomedicum, Tallinn University of Technology, Ehitajate tee 5, EST-19086 Tallinn, EstoniaDepartment of Biomedical Engineering, Technomedicum, Tallinn University of Technology, Ehitajate tee 5, EST-19086 Tallinn, EstoniaThe aim of this study was to estimate the concentration of uric acid (UA) optically by using the original and processed ultraviolet (UV) absorbance spectra of spent dialysate. Also, the effect of using several wavelengths (multi-wavelength algorithms) for estimation was examined. This paper gives an overview of seven studies carried out in Linköping, Sweden, and Tallinn, Estonia. A total of 60 patients were monitored over their 188 dialysis treatment procedures. Dialysate samples were taken and analysed by means of UA concentration in a chemical laboratory and with a double-beam spectrophotometer. The measured UV absorbance spectra were processed. Three models for the original and three for the first derivate of UV absorbance were created; concentrations of UA from the different methods were finally compared in terms of mean values and SD. The mean concentration (micromol/L) of UA was 49.7±23.0 measured in the chemical laboratory, and 48.9±22.4 calculated with the best estimate among all models. The concentrations were not significantly different (P≥0.17). It was found that using a multi-wavelength and processed signal approach leads to more accurate results, and therefore these approaches should be used in future.http://dx.doi.org/10.1100/2012/506486 |
| spellingShingle | Jana Holmar Ivo Fridolin Fredrik Uhlin Kai Lauri Merike Luman Optical Method for Cardiovascular Risk Marker Uric Acid Removal Assessment during Dialysis The Scientific World Journal |
| title | Optical Method for Cardiovascular Risk Marker Uric Acid Removal Assessment during Dialysis |
| title_full | Optical Method for Cardiovascular Risk Marker Uric Acid Removal Assessment during Dialysis |
| title_fullStr | Optical Method for Cardiovascular Risk Marker Uric Acid Removal Assessment during Dialysis |
| title_full_unstemmed | Optical Method for Cardiovascular Risk Marker Uric Acid Removal Assessment during Dialysis |
| title_short | Optical Method for Cardiovascular Risk Marker Uric Acid Removal Assessment during Dialysis |
| title_sort | optical method for cardiovascular risk marker uric acid removal assessment during dialysis |
| url | http://dx.doi.org/10.1100/2012/506486 |
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