Modular strategy with autologous bioreactor: a potential way for organ engineering
Bioengineered organs have been seen as a promising strategy to address the shortage of transplantable organs. However, it is still difficult to achieve heterogeneous structures and complex functions similar to natural organs using current bioengineering techniques. This work introduces the methods a...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2024-01-01
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| Series: | International Journal of Extreme Manufacturing |
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| Online Access: | https://doi.org/10.1088/2631-7990/ad92c9 |
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| author | Qingfeng Bai Hai Tang Yi Chen Ziyin Pan Weikang Lin Lei Wang Yulong Hu Boyu Xu Minglei Yang Guofang Zhao Weiyan Sun Yong He Chang Chen |
| author_facet | Qingfeng Bai Hai Tang Yi Chen Ziyin Pan Weikang Lin Lei Wang Yulong Hu Boyu Xu Minglei Yang Guofang Zhao Weiyan Sun Yong He Chang Chen |
| author_sort | Qingfeng Bai |
| collection | DOAJ |
| description | Bioengineered organs have been seen as a promising strategy to address the shortage of transplantable organs. However, it is still difficult to achieve heterogeneous structures and complex functions similar to natural organs using current bioengineering techniques. This work introduces the methods and dilemmas in organ engineering and existing challenges. Furthermore, a new roadmap for organ engineering, which uses a modular strategy with autologous bioreactors to create organ-level bioengineered constructions, is summarized based on the latest research advances. In brief, different functional modules of natural organs are constructed in vitro , and autologous bioreactors in vivo are utilized to facilitate inter-module assembly to form a complete bioengineered organ capable of replacing natural organ functions. There are bioengineered organs, such as biomimetic tracheas, which have been successfully fabricated following this roadmap. This new roadmap for organ engineering shows prospects in addressing the shortage of transplantable organs and has broad prospects for clinical applications. |
| format | Article |
| id | doaj-art-0acf5712f28d442f93d60e45dfe4067a |
| institution | OA Journals |
| issn | 2631-7990 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | International Journal of Extreme Manufacturing |
| spelling | doaj-art-0acf5712f28d442f93d60e45dfe4067a2025-08-20T02:27:07ZengIOP PublishingInternational Journal of Extreme Manufacturing2631-79902024-01-017202200110.1088/2631-7990/ad92c9Modular strategy with autologous bioreactor: a potential way for organ engineeringQingfeng Bai0Hai Tang1Yi Chen2Ziyin Pan3Weikang Lin4Lei Wang5Yulong Hu6Boyu Xu7Minglei Yang8Guofang Zhao9Weiyan Sun10Yong He11https://orcid.org/0000-0002-9099-0831Chang Chen12https://orcid.org/0000-0002-9981-3110Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaDepartment of Cardiothoracic Surgery, Ningbo No. 2 Hospital , Ningbo, People’s Republic of ChinaDepartment of Cardiothoracic Surgery, Ningbo No. 2 Hospital , Ningbo, People’s Republic of ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University , Hangzhou, People’s Republic of China; Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University , Hangzhou, People’s Republic of ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine , Shanghai, People’s Republic of China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital, Tongji University , Shanghai, People’s Republic of ChinaBioengineered organs have been seen as a promising strategy to address the shortage of transplantable organs. However, it is still difficult to achieve heterogeneous structures and complex functions similar to natural organs using current bioengineering techniques. This work introduces the methods and dilemmas in organ engineering and existing challenges. Furthermore, a new roadmap for organ engineering, which uses a modular strategy with autologous bioreactors to create organ-level bioengineered constructions, is summarized based on the latest research advances. In brief, different functional modules of natural organs are constructed in vitro , and autologous bioreactors in vivo are utilized to facilitate inter-module assembly to form a complete bioengineered organ capable of replacing natural organ functions. There are bioengineered organs, such as biomimetic tracheas, which have been successfully fabricated following this roadmap. This new roadmap for organ engineering shows prospects in addressing the shortage of transplantable organs and has broad prospects for clinical applications.https://doi.org/10.1088/2631-7990/ad92c9bioengineered organsartificial organsorgan-levelautologous bioreactor |
| spellingShingle | Qingfeng Bai Hai Tang Yi Chen Ziyin Pan Weikang Lin Lei Wang Yulong Hu Boyu Xu Minglei Yang Guofang Zhao Weiyan Sun Yong He Chang Chen Modular strategy with autologous bioreactor: a potential way for organ engineering International Journal of Extreme Manufacturing bioengineered organs artificial organs organ-level autologous bioreactor |
| title | Modular strategy with autologous bioreactor: a potential way for organ engineering |
| title_full | Modular strategy with autologous bioreactor: a potential way for organ engineering |
| title_fullStr | Modular strategy with autologous bioreactor: a potential way for organ engineering |
| title_full_unstemmed | Modular strategy with autologous bioreactor: a potential way for organ engineering |
| title_short | Modular strategy with autologous bioreactor: a potential way for organ engineering |
| title_sort | modular strategy with autologous bioreactor a potential way for organ engineering |
| topic | bioengineered organs artificial organs organ-level autologous bioreactor |
| url | https://doi.org/10.1088/2631-7990/ad92c9 |
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