Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemias in the northern Dutch-German cross-border region: a ten-year multicentre analysis
INTRODUCTION: Enterococcus species, particularly E. faecium and E. faecalis, are prominent causes of bacteraemia, posing significant clinical challenges due to antibiotic resistance. The incidence of enterococcal bacteraemia, especially vancomycin-resistant E. faecium (VREfm), has been rising in Eur...
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524002261 |
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| author | Cansu Çimen Andreas Voss Joseph Hellkamp Axel Hamprecht Matthijs Berends |
| author_facet | Cansu Çimen Andreas Voss Joseph Hellkamp Axel Hamprecht Matthijs Berends |
| author_sort | Cansu Çimen |
| collection | DOAJ |
| description | INTRODUCTION: Enterococcus species, particularly E. faecium and E. faecalis, are prominent causes of bacteraemia, posing significant clinical challenges due to antibiotic resistance. The incidence of enterococcal bacteraemia, especially vancomycin-resistant E. faecium (VREfm), has been rising in Europe. This study aims to map the trends in enterococcal bacteraemia and VREfm in the Northern Dutch-German cross-border region over a decade. METHODS: We conducted a retrospective cross-sectional study at the Dutch University Medical Center Groningen (UMCG) and German Klinikum Oldenburg (KOL) from January 1, 2013, to December 31, 2022. Data on enterococcal bacteraemia episodes, patient demographics, and antibiotic resistance were collected from blood cultures. RESULTS: A total of 1,822 episodes of enterococcal bacteraemia were identified, of which 733 at KOL and 1,089 at UMCG. VRE bacteraemia was significantly higher at KOL (67 cases) compared to UMCG (7 cases). Median ages for enterococcal bacteraemia were 67 years at KOL and 61 years at UMCG. The majority of cases were in males (68.2% at KOL, 63.4% at UMCG). Haematology/Oncology wards accounted for approximately 48% of enterococcal bacteraemia cases in both hospitals. DISCUSSION: Our findings reveal significant institutional and regional differences in the incidence and characteristics of enterococcal bacteraemia. These discrepancies highlight the need for localized surveillance for understanding the epidemiology of enterococcal bacteraemia, and tailored infection control strategies. The high burden of bacteraemia in Haematology/Oncology wards underscores the vulnerability of immunocompromised patients. Enhanced cross-border collaboration and data sharing are crucial for effective infection control in this interconnected region. |
| format | Article |
| id | doaj-art-0ace71451ac64a8cb7903aaec1c8206b |
| institution | DOAJ |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-0ace71451ac64a8cb7903aaec1c8206b2025-08-20T02:57:26ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-01391610.1016/j.jgar.2024.10.049Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemias in the northern Dutch-German cross-border region: a ten-year multicentre analysisCansu Çimen0Andreas Voss1Joseph Hellkamp2Axel Hamprecht3Matthijs Berends4University of Groningen, Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, The NetherlandsUniversity of Groningen, Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, The NetherlandsInstitute for Medical Microbiology and Virology, Klinikum Oldenburg, Oldenburg, GermanyInstitute for Medical Microbiology and Virology, Klinikum Oldenburg, Oldenburg, GermanyUniversity of Groningen, Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, The NetherlandsINTRODUCTION: Enterococcus species, particularly E. faecium and E. faecalis, are prominent causes of bacteraemia, posing significant clinical challenges due to antibiotic resistance. The incidence of enterococcal bacteraemia, especially vancomycin-resistant E. faecium (VREfm), has been rising in Europe. This study aims to map the trends in enterococcal bacteraemia and VREfm in the Northern Dutch-German cross-border region over a decade. METHODS: We conducted a retrospective cross-sectional study at the Dutch University Medical Center Groningen (UMCG) and German Klinikum Oldenburg (KOL) from January 1, 2013, to December 31, 2022. Data on enterococcal bacteraemia episodes, patient demographics, and antibiotic resistance were collected from blood cultures. RESULTS: A total of 1,822 episodes of enterococcal bacteraemia were identified, of which 733 at KOL and 1,089 at UMCG. VRE bacteraemia was significantly higher at KOL (67 cases) compared to UMCG (7 cases). Median ages for enterococcal bacteraemia were 67 years at KOL and 61 years at UMCG. The majority of cases were in males (68.2% at KOL, 63.4% at UMCG). Haematology/Oncology wards accounted for approximately 48% of enterococcal bacteraemia cases in both hospitals. DISCUSSION: Our findings reveal significant institutional and regional differences in the incidence and characteristics of enterococcal bacteraemia. These discrepancies highlight the need for localized surveillance for understanding the epidemiology of enterococcal bacteraemia, and tailored infection control strategies. The high burden of bacteraemia in Haematology/Oncology wards underscores the vulnerability of immunocompromised patients. Enhanced cross-border collaboration and data sharing are crucial for effective infection control in this interconnected region.http://www.sciencedirect.com/science/article/pii/S2213716524002261bacteraemiaenterococcusEnterococcus faecalisvancomycin-resistant Enterococcus faeciumcross-border healthcare |
| spellingShingle | Cansu Çimen Andreas Voss Joseph Hellkamp Axel Hamprecht Matthijs Berends Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemias in the northern Dutch-German cross-border region: a ten-year multicentre analysis Journal of Global Antimicrobial Resistance bacteraemia enterococcus Enterococcus faecalis vancomycin-resistant Enterococcus faecium cross-border healthcare |
| title | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemias in the northern Dutch-German cross-border region: a ten-year multicentre analysis |
| title_full | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemias in the northern Dutch-German cross-border region: a ten-year multicentre analysis |
| title_fullStr | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemias in the northern Dutch-German cross-border region: a ten-year multicentre analysis |
| title_full_unstemmed | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemias in the northern Dutch-German cross-border region: a ten-year multicentre analysis |
| title_short | Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemias in the northern Dutch-German cross-border region: a ten-year multicentre analysis |
| title_sort | temporal trends of enterococcal and vancomycin resistant enterococcus faecium bacteraemias in the northern dutch german cross border region a ten year multicentre analysis |
| topic | bacteraemia enterococcus Enterococcus faecalis vancomycin-resistant Enterococcus faecium cross-border healthcare |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524002261 |
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