Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful?
BACKGROUND: Systemic approaches are needed to understand how variations in the genes associated with opioid pharmacokinetics and response can be used to predict patient outcome. The application of pharmacogenetic analysis to two cases of life-threatening opioid-induced respiratory depression is pres...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2013/518012 |
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| _version_ | 1850232470376546304 |
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| author | Parvaz Madadi Johanna Sistonen Gregory Silverman Rebecca Gladdy Colin J Ross Bruce C Carleton Jose C Carvalho Michael R Hayden Gideon Koren |
| author_facet | Parvaz Madadi Johanna Sistonen Gregory Silverman Rebecca Gladdy Colin J Ross Bruce C Carleton Jose C Carvalho Michael R Hayden Gideon Koren |
| author_sort | Parvaz Madadi |
| collection | DOAJ |
| description | BACKGROUND: Systemic approaches are needed to understand how variations in the genes associated with opioid pharmacokinetics and response can be used to predict patient outcome. The application of pharmacogenetic analysis to two cases of life-threatening opioid-induced respiratory depression is presented. The usefulness of genotyping in the context of these cases is discussed. |
| format | Article |
| id | doaj-art-0acaa1ee33b047b58f4731ee7fa292f5 |
| institution | OA Journals |
| issn | 1203-6765 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-0acaa1ee33b047b58f4731ee7fa292f52025-08-20T02:03:12ZengWileyPain Research and Management1203-67652013-01-0118313313610.1155/2013/518012Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful?Parvaz Madadi0Johanna Sistonen1Gregory Silverman2Rebecca Gladdy3Colin J Ross4Bruce C Carleton5Jose C Carvalho6Michael R Hayden7Gideon Koren8Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, CanadaCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, CanadaDepartment of Surgery, Mount Sinai Hospital, Toronto, Ontario, CanadaCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, CanadaChild and Family Research Institute, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, CanadaCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, CanadaClinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, CanadaBACKGROUND: Systemic approaches are needed to understand how variations in the genes associated with opioid pharmacokinetics and response can be used to predict patient outcome. The application of pharmacogenetic analysis to two cases of life-threatening opioid-induced respiratory depression is presented. The usefulness of genotyping in the context of these cases is discussed.http://dx.doi.org/10.1155/2013/518012 |
| spellingShingle | Parvaz Madadi Johanna Sistonen Gregory Silverman Rebecca Gladdy Colin J Ross Bruce C Carleton Jose C Carvalho Michael R Hayden Gideon Koren Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful? Pain Research and Management |
| title | Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful? |
| title_full | Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful? |
| title_fullStr | Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful? |
| title_full_unstemmed | Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful? |
| title_short | Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful? |
| title_sort | life threatening adverse events following therapeutic opioid administration in adults is pharmacogenetic analysis useful |
| url | http://dx.doi.org/10.1155/2013/518012 |
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