Age-related alterations in functional and structural networks in the brain in macaque monkeys
Resting-state networks (RSNs) have been used as biomarkers of brain diseases and cognitive performance. However, age-related changes in the RSNs of macaques, a representative animal model, are still not fully understood. In this study, we measured the RSNs in macaques aged 3–20 years and investigate...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnana.2025.1495735/full |
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| author | Kazuya Ouchi Kazuya Ouchi Shinya Yamamoto Shinya Yamamoto Makoto Obara Yasuko Sugase-Miyamoto Tomokazu Tsurugizawa Tomokazu Tsurugizawa Tomokazu Tsurugizawa |
| author_facet | Kazuya Ouchi Kazuya Ouchi Shinya Yamamoto Shinya Yamamoto Makoto Obara Yasuko Sugase-Miyamoto Tomokazu Tsurugizawa Tomokazu Tsurugizawa Tomokazu Tsurugizawa |
| author_sort | Kazuya Ouchi |
| collection | DOAJ |
| description | Resting-state networks (RSNs) have been used as biomarkers of brain diseases and cognitive performance. However, age-related changes in the RSNs of macaques, a representative animal model, are still not fully understood. In this study, we measured the RSNs in macaques aged 3–20 years and investigated the age-related changes from both functional and structural perspectives. The proportion of structural connectivity in the RSNs relative to the total fibers in the whole brain significantly decreased in aged macaques, whereas functional connectivity showed an increasing trend with age. Additionally, the amplitude of low-frequency fluctuations tended to increase with age, indicating that resting-state neural activity may be more active in the RSNs may increase with age. These results indicate that structural and functional alterations in typical RSNs are age-dependent and can be a marker of aging in the macaque’s brain. |
| format | Article |
| id | doaj-art-0ac80fd51b2647d2a668c527432bf6c2 |
| institution | DOAJ |
| issn | 1662-5129 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj-art-0ac80fd51b2647d2a668c527432bf6c22025-08-20T02:40:33ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292025-03-011910.3389/fnana.2025.14957351495735Age-related alterations in functional and structural networks in the brain in macaque monkeysKazuya Ouchi0Kazuya Ouchi1Shinya Yamamoto2Shinya Yamamoto3Makoto Obara4Yasuko Sugase-Miyamoto5Tomokazu Tsurugizawa6Tomokazu Tsurugizawa7Tomokazu Tsurugizawa8Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, JapanFaculty of Engineering, Information and Systems, University of Tsukuba, Tsukuba, JapanHuman Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, JapanGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, JapanPhilips Japan Ltd, Tokyo, JapanHuman Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, JapanHuman Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, JapanFaculty of Engineering, Information and Systems, University of Tsukuba, Tsukuba, JapanUniversité du Québec à Trois-Rivières, Trois-Rivières, QC, CanadaResting-state networks (RSNs) have been used as biomarkers of brain diseases and cognitive performance. However, age-related changes in the RSNs of macaques, a representative animal model, are still not fully understood. In this study, we measured the RSNs in macaques aged 3–20 years and investigated the age-related changes from both functional and structural perspectives. The proportion of structural connectivity in the RSNs relative to the total fibers in the whole brain significantly decreased in aged macaques, whereas functional connectivity showed an increasing trend with age. Additionally, the amplitude of low-frequency fluctuations tended to increase with age, indicating that resting-state neural activity may be more active in the RSNs may increase with age. These results indicate that structural and functional alterations in typical RSNs are age-dependent and can be a marker of aging in the macaque’s brain.https://www.frontiersin.org/articles/10.3389/fnana.2025.1495735/fullmacaque monkeyfunctional connectivitystructural connectivitynetworkMRI |
| spellingShingle | Kazuya Ouchi Kazuya Ouchi Shinya Yamamoto Shinya Yamamoto Makoto Obara Yasuko Sugase-Miyamoto Tomokazu Tsurugizawa Tomokazu Tsurugizawa Tomokazu Tsurugizawa Age-related alterations in functional and structural networks in the brain in macaque monkeys Frontiers in Neuroanatomy macaque monkey functional connectivity structural connectivity network MRI |
| title | Age-related alterations in functional and structural networks in the brain in macaque monkeys |
| title_full | Age-related alterations in functional and structural networks in the brain in macaque monkeys |
| title_fullStr | Age-related alterations in functional and structural networks in the brain in macaque monkeys |
| title_full_unstemmed | Age-related alterations in functional and structural networks in the brain in macaque monkeys |
| title_short | Age-related alterations in functional and structural networks in the brain in macaque monkeys |
| title_sort | age related alterations in functional and structural networks in the brain in macaque monkeys |
| topic | macaque monkey functional connectivity structural connectivity network MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnana.2025.1495735/full |
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