JS-K induces ferroptosis in renal carcinoma cells by regulating the c-Myc-GSTP1 Axis

JS-K induces ferroptosis in renal carcinoma cells by regulating the c-Myc-GSTP1 Axis

Abstract JS-K is a precursor drug of nitric oxide (NO) and inhibits tumor growth through various mechanisms. Ferroptosis, a form of cell death closely related to lipid peroxidation, is increasingly being recognized for its role in cancer biology. However, the relevance of ferroptosis in the anti-tum...

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Bibliographic Details
Main Authors: Yuwan Zhao, LuGang Zhu, Xinghua Lin, Bin Li, Bailiang Miu, Jingping Qiu, Sheng Gao, Jianjun Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Renal cell carcinoma
JS-K
c-Myc
GSTP1
Ferroptosis
Online Access:https://doi.org/10.1038/s41598-025-97887-3
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