Comparison of immunological and immunogenetic markers in recent-onset type 1 diabetes among children and adults

Comparison of immunological and immunogenetic markers in recent-onset type 1 diabetes among children and adults

Abstract This study aimed to compare the immunological and immunogenetic profiles over a spectrum of childhood- and adulthood-onset T1D at diagnosis. The cross-sectional study involved participants with recently diagnosed T1D (n = 168), aged 2.9–68.2 years. HLA-II alleles, single nucleotide polymorp...

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Main Authors: Kristi Alnek, Aili Tagoma, Kaja Metsküla, Ija Talja, Helis Janson, Maire Mandel, Tamara Vorobjova, Astrid Oras, Hanna Sepp, Katrin Pruul, Koit Reimand, Tiia Simonen, Aleksandr Peet, Ingrid Reppo, Kaia Tammiksaar, Maire Lubi, Kaire Heilman, Ülle Einberg, Kalle Kisand, Margus Lember, Vallo Tillmann, Raivo Uibo
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Adults
Autoantibodies
Autoantibody-negative
Children
Enterovirus antibodies
HLA
Online Access:https://doi.org/10.1038/s41598-025-99664-8
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