The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome
Background and Aim: Diabetes, along with morphine, can lead to metabolic damage in testicular tissue through oxidative stress. This study aimed at investigating the effects of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in the testicular tissue of dia...
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Kashan University of Medical Sciences
2024-04-01
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| Series: | مجله علوم پزشکی فیض (پیوسته) |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-5009-en.pdf |
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| author | Shahram Azarrang Mohammad Parastesh Abbas Saremi |
| author_facet | Shahram Azarrang Mohammad Parastesh Abbas Saremi |
| author_sort | Shahram Azarrang |
| collection | DOAJ |
| description | Background and Aim: Diabetes, along with morphine, can lead to metabolic damage in testicular tissue through oxidative stress. This study aimed at investigating the effects of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in the testicular tissue of diabetic rats with acute morphine withdrawal syndrome.
Methods: In this experimental study, 32 male Wistar rats were randomly divided into four groups of eight: 1) diabetes control, 2) morphine + diabetes, 3) diabetes + moderate-intensity endurance training, and 4) morphine + diabetes + moderate-intensity endurance training. Diabetes was induced and morphine was administered to create the acute morphine withdrawal syndrome. The training groups underwent an eight-week endurance training protocol. Oxidant and antioxidant indices, including MDA, TAC, GPX, and SOD, were measured in the testicular tissue at the end of the study.
Results: The concentration of the oxidant index MDA significantly increased in the diabetes group compared to the other groups (P=0.001). However, moderate-intensity endurance training led to a significant decrease in MDA concentration (P=0.001) and a significant increase in the levels of antioxidant indices (TAC, GPX, and SOD) compared to the diabetes group (P=0.001).
Conclusion: Moderate-intensity endurance training could reduce the oxidant index and increase antioxidant indices in the testicular tissue of diabetic rats with morphine withdrawal syndrome. This suggests a potential reduction in infertility complications in these rats. |
| format | Article |
| id | doaj-art-0aa21dbf99c34b91b2a2ff3e3cdddcd6 |
| institution | DOAJ |
| issn | 3060-5806 3060-5814 |
| language | fas |
| publishDate | 2024-04-01 |
| publisher | Kashan University of Medical Sciences |
| record_format | Article |
| series | مجله علوم پزشکی فیض (پیوسته) |
| spelling | doaj-art-0aa21dbf99c34b91b2a2ff3e3cdddcd62025-08-20T02:51:19ZfasKashan University of Medical Sciencesمجله علوم پزشکی فیض (پیوسته)3060-58063060-58142024-04-01282149158The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndromeShahram Azarrang0Mohammad Parastesh1Abbas Saremi2 Department of Physical Education and Sports Sciences, Borujard Branch, Islamic Azad University, Borujard, Iran Department of Sports Physiology and Pathology, Faculty of Sports Sciences, Arak University, Arak, Iran Department of Sports Physiology and Pathology, Faculty of Sports Sciences, Arak University, Arak, Iran Background and Aim: Diabetes, along with morphine, can lead to metabolic damage in testicular tissue through oxidative stress. This study aimed at investigating the effects of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in the testicular tissue of diabetic rats with acute morphine withdrawal syndrome. Methods: In this experimental study, 32 male Wistar rats were randomly divided into four groups of eight: 1) diabetes control, 2) morphine + diabetes, 3) diabetes + moderate-intensity endurance training, and 4) morphine + diabetes + moderate-intensity endurance training. Diabetes was induced and morphine was administered to create the acute morphine withdrawal syndrome. The training groups underwent an eight-week endurance training protocol. Oxidant and antioxidant indices, including MDA, TAC, GPX, and SOD, were measured in the testicular tissue at the end of the study. Results: The concentration of the oxidant index MDA significantly increased in the diabetes group compared to the other groups (P=0.001). However, moderate-intensity endurance training led to a significant decrease in MDA concentration (P=0.001) and a significant increase in the levels of antioxidant indices (TAC, GPX, and SOD) compared to the diabetes group (P=0.001). Conclusion: Moderate-intensity endurance training could reduce the oxidant index and increase antioxidant indices in the testicular tissue of diabetic rats with morphine withdrawal syndrome. This suggests a potential reduction in infertility complications in these rats.http://feyz.kaums.ac.ir/article-1-5009-en.pdfmoderate-intensity endurance trainingdiabetesmorphineantioxidant indicatorsmalondialdehyde |
| spellingShingle | Shahram Azarrang Mohammad Parastesh Abbas Saremi The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome مجله علوم پزشکی فیض (پیوسته) moderate-intensity endurance training diabetes morphine antioxidant indicators malondialdehyde |
| title | The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome |
| title_full | The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome |
| title_fullStr | The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome |
| title_full_unstemmed | The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome |
| title_short | The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome |
| title_sort | effect of eight weeks of moderate intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome |
| topic | moderate-intensity endurance training diabetes morphine antioxidant indicators malondialdehyde |
| url | http://feyz.kaums.ac.ir/article-1-5009-en.pdf |
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